99.87% Purity White Local Anaesthesia Drugs CAS 59-46-1 White Crystalline Powder Procaine
Description:
Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as Procaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine was first synthesized in 1905, shortly after amylocaine. It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Procaine, from the Latin nov- (meaning new) and -caine, a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, was the most commonly used local anesthetic.[citation needed] Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this[why?] and spent many years touring dental schools to advise them not to use it.
Quick Detail:
Product Name: Procaine
Synonyms: 2-(Diethylamino)ethyl 4-aminobenzoate;2-(Diethylamino)ethyl p-aminobenzoate;2-(diethylamino)ethylp-aminobenzoate;2-diethylaminoethyl4-aminobenzoate;2-Diethylaminoethylester kyseliny p-aminobenzoove;2-diethylaminoethylesterkyselinyp-aminobenzoove;2-diethylaminoethylp-aminobenzoate;4-Aminobenzoic acid diethylaminoethyl ester
CAS: 59-46-1
MF: C13H20N2O2
MW: 236.31
EINECS: 200-426-9
Assay:99.87%
Standard: BP/USP/EP
Appearance: White crystalline powder
Usage: Inhibitor of sodium channel
COA:
| Items |
Specification |
Test Results |
| Appearance |
White crystals or a white crystalline powder |
Conform |
| Identification |
ABE. It appears positive reaction |
| Melting point |
154degree~158degree |
154degree~157degree |
| Acidity |
PH 5.0~6.5 |
PH=5.9 |
| Appearance of solution |
Clear and colourless |
Conform |
| Loss on drying |
≤0.5% |
0.07% |
| Heavy metals |
≤0.0005% |
Conform |
| Related substances |
≤0.05% |
Conform |
| Sulphated ash |
≤0.1% |
0.05% |
| Assay ( on dry basis ) |
99.0-101.0% |
99.87% |
| Conclusion |
Conform to BP2005 |
Application:
Procaine is a local anesthetic. Procaine causes loss of feeling of skin and mucous membranes.Procaine is used as an injection during surgery and other medical and dental procedures.Procaine may also be used for purposes other than those listed here.
Procaine is a chemical. People use it for medicine. Be careful not to confuse the procaine used by mouth with the prescription procaine given by injection only under the supervision of a healthcare professional. Procaine is taken by mouth or given as a shot for arthritis, “hardening of the arteries” in the brain, dementia, depression, hair loss, high blood pressure, and sexual performance problems.As a prescription-only injection, procaine is used for local anesthesia.
It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block
Procaine is used as an injection during surgery and other medical and dental procedures. Procaine suggested for use in reversing aging in modern times, it could be used to combat arthritis, arteriosclerosis, senile skin changes and baldness. Procaine containing benzoic acid has beenshown to markedly improve the absorption of procaine by fats, thus quickening its absorption by the human body. Procaine also increases the speed with which the nerves conduct impulses, and decreases the rate of excretion of the 17 kerosteroids, which usually increases with age. Procaine's anti-aging benefits include increased nerve velocities, improved sense of well-being and increased potential life span.
Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.
Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.
A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.
The primary use for procaine is as a topical anaesthetic.Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is often coadministered with epinephrine for the purpose of vasoconstriction.
Usage:
Procaine is a kind of local anesthetics. With low toxicity but quick and safe effects, procaine is suitable for local anesthesia, applied to the eye, ear, nose, teeth and other department operation, used for infiltration anesthesia, anesthesia and closed therapy supervisor. Procaine is also used in the production of procaine penicillin.Procaine causes loss of feeling (numbness) of skin and mucous membranes. Procaine is used as an injection during surgery and other medical and dental procedures.
Procaine application before removal of a decayed toothThe primary use for procaine is as an anaesthetic.
Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction.
Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.
Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.
Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.
A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10ml of 1% procaine), as it helps relieve pain and vascular spasm.
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Local Anesthesia:
| Benzocaine |
Prilocaine |
Propitocaine hydrochloride |
| Bupivacaine |
Tetracaine |
Proparacaine hydrochloride |
| Lidocaine |
Tetracaine hydrochloride |
Bupivacaine hydrochloride |
| Linocaine hydrochloride |
Pramoxine hydrochloride |
Dibucaine hydrochloride |
| Procaine |
Articaine hydrochloride |
Ropivacaine hydrochloride |
| Procaine hydrochloride |
Benzocaine hydrochloride |
Levobupivacaine Hcl |
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