Local Anesthetic Drug Procaine Cas: 59-46-1 for Relieving Pain
Description:
Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions, procaine is referred to generically as novocaine. It acts mainly as a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion-enhancing, and mood-enhancing effects.
Procaine was first synthesized in 1905,shortly after amylocaine.It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin nov- (meaning "new") and -caine, a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, cocaine was a commonly used local anesthetic.Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful.
Basic information:
Product Name: Procaine
Cas No: 59-46-1
Molecular Formula: C13H20N2O2
Appearance: White powder
Application: Medicine and health care
PackAge: 1kg/bag ,25kg/drum..
Production Capacity: 500 Kilogram/Month.
Purity: 98%....
Storage: Keep away from light at normal temper
Transportation: Express delivery
LimitNum: 1 Kilogram
Heavy Metal: ＜1ppm
Valid Period: 2 years
Grade: Pharma Grade
COA:
| Product name |
Procaine
|
||
| CAS No. | 59-46-1 | Outer Packing | 25KG |
| Production date | 2017.10.01 | Shelf life | 2019.09.30 |
|
Standard adopted |
Enterprise standard
|
||
| Items of analysis | Specification | Results | |
|
Assay
|
≥99%
|
99.7%
|
|
|
Loss on dry
|
≤0.5%
|
0.38%
|
|
|
Melting point
|
55-63℃
|
59-61℃
|
|
|
Appearance
|
White or white crystalline powder |
white crystalline powder |
|
| Conclusion | Qualified | ||
How does it work?
Procaine works as an anesthetic when injected. However, procaine doesn’t get absorbed well when it is taken by mouth. It is unclear how it might work for medicinal uses when taken by mouth.
Procaine is only found in individuals that have used or taken this drug. It is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). [PubChem]Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
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