Antifungal Drug Ketoconazole CAS: 65277-42-1 Raw Powder 99% Purity
Description:
Ketoconazole is a synthetic imidazole antifungal drug used primarily to treat fungal infections. Ketoconazole is sold commercially as a tablet for oral administration (although this use has been discontinued in a number of countries), and in a variety of formulations for topical administration, such as creams (used to treat tinea; cutaneous candidiasis, including candidal paronychia; and pityriasis versicolor) and shampoos (used primarily to treat dandruff-seborrhoeic dermatitis of the scalp).
The less toxic and generally more effective triazole antifungal agents fluconazole and itraconazole are usually preferred for systemic use. In 2013 the European Medicines Agency's Committee on Medicinal Products for Human Use (CHMP) recommended that a ban be imposed on the use of oral ketoconazole for systemic use in humans throughout the European Union, after concluding that the risk of serious liver injury from systemic ketoconazole outweighs its benefits.The oral formulation of ketoconazole was discontinued in Australia in 2013 and in China in 2015.
Basic information:
Chemical name: Ketoconazole
MF: C26H28Cl2N4O4
MW: 531.43
CAS: 65277-42-1
Appearance: white powder
Purity: over 99%
Package: 25kg
COA:
| Product name | Ketoconazole | ||
| CAS No. | 65277-42-1 | Outer Packing | 25KGDrum |
| Production date | 2014-07-10 | Shelf life | 2015-07-09 |
| Standard adopted | company standard | ||
| Items of analysis | Specification | Results | |
| Appearance | A white or almost white powder. | Qualified | |
| Identification | IR | Qualified | |
| Melting range | 148.0-152.0℃ | 148.0-150.0℃ | |
| Specific rotation | ﹣1º～ ﹢1º | 0° | |
| Loss on drying | ≤0.5% | 0.16% | |
| Residue on ignition | ≤0.1% | 0.05% | |
| Chromatographic purity | ≤2.0% | Qualified | |
| Assay | 98.0%～102.0% | 98.5% | |
| Conclusion | Qualified | ||
Usage:
Ketoconazole is used to treat certain serious fungal infections in the body. Ketoconazole belongs to the class of drugs called azole antifungals. It works by stopping the growth of the fungus.
Ketoconazole should not be used to treat fungal infections on the skin and nails due to the risk of serious side effects and drug interactions. Talk to your doctor about other medications you can use to treat these types of infection.
How should this medicine be used?
Prescription ketoconazole comes as a cream and a shampoo to apply to the skin. Over-the-counter ketoconazole comes as a shampoo to apply to the scalp. Ketoconazole cream is usually applied once a day for 2 to 6 weeks. Prescription ketoconazole shampoo is usually applied one time to treat the infection. Over-the-counter ketoconazole shampoo is usually used every 3 to 4 days for up to 8 weeks, and then used as needed to control dandruff. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use ketoconazole exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
One treatment with prescription ketoconazole shampoo may successfully treat your tinea versicolor infection. However, it may take several months for your skin color to return to normal, especially if your skin is exposed to sunlight. After your infection is treated, there is a chance that you will develop another tinea versicolor infection.
If you are using over-the-counter ketoconazole shampoo to treat dandruff, your symptoms should improve during the first 2 to 4 weeks of your treatment. Call your doctor if your symptoms do not improve during this time or if your symptoms get worse at any time during your treatment.
If you are using ketoconazole cream, your symptoms should improve at the beginning of your treatment. Continue to use ketoconazole cream even if you are feeling well. If you stop using ketoconazole cream too soon, your infection may not be completely cured and your symptoms may return.
Ketoconazole cream and shampoos are only for use on the skin or scalp. Do not let ketoconazole cream or shampoo get into your eyes or mouth, and do not swallow the medication. If you do get ketoconazole cream or shampoo in your eyes, wash them with plenty of water.
To use the cream, apply enough cream to cover the affected area and all of the skin around it.
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