Antihypertensive Drugs Telmisartan Raw Powder CAS: 144701-48-4
What is telmisartan (Micardis)?
Telmisartan is an angiotensin II receptor antagonist. Telmisartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.
Telmisartan is used to treat high blood pressure (hypertension). It is sometimes given together with other blood pressure medications.
Telmisartan is also used to reduce the risk of stroke, heart attack, or death from heart problems in people who are at least 55 years old with risk factors for serious heart disorders.
Telmisartan may also be used for purposes not listed in this medication guide.
Basic information:
Chemical name: Telmisartan
MF: C33H30N4O2
MW: 514.63
CAS: 144701-48-4
Appearance: white powder
Purity: over 99%
Appearance: white powder
Package: 25kg
Usage: antihypertensive drugs
Basic information:
| Product name | TELMISARTAN | ||
| CAS No. | 144701-48-4 | Outer Packing | 25KG |
| Production date | 2016-5-30 | Shelf life | 2018-5-29 |
| Standard adopted | EP7.0 | ||
| Items of analysis | Specification | Results | |
| Appearance | White or slightly yellowish,crystalline powder | Conform | |
| Solubility | Insoluble water,slightly soluble in methanol,sparingly soluble in methylene chloride.It dissolves in 1M sodium hydroxide. | Conform | |
| A | Infra-red absorption spectrum should be identical with contrast. | Contorm | |
| Appearance of solution | Dissolve 0.5g in 1M sodium hydroxide and dilute to 10ml with the same solvent:NMT Y4 | Contorm | |
| Related substances | Impurities C:NMT 0.2% | Unfound | |
| Related substances | Impurities D:NMT 0.2% | 0.04% | |
| Related substances | Impurities A:NMT 0.15% | 0.005% | |
| Related substances | Impurities B:NMT 0.15% | 0.006% | |
| Related substances | Unspecified impurities:NMT 0.1% | 0.05% | |
| Related substances | Total impurities:NMT 1.0% | 0.27% | |
| Loss on drying | NMT 0.5% | 0.5% | |
| Sulphated ash | NMT 0.1% | 0.05% | |
| Residual Solvents | Methanol:NMT 3000ppm | Unfound | |
| Residual Solvents | 1,2-dimethoxyethane:NMT 100ppm | Unfound | |
| Residual Solvents | Ethanol:NMT 5000ppm | Unfound | |
| Residual Solvents | Acetic acid:NMT 5000ppm | Unfound | |
| ASSAY | 99.0%~101.0% | 100.0% | |
| Conclusion | Qualified | ||
BACKGROUND:
Telmisartan is an angiotensin II receptor antagonist marketed around the world to treat elevated blood pressure and reduce the risk of cardiovascular risk associated with chronic hypertension. Telmisartan is an alternative medication for people who are unable to take angiotensin-converting enzyme (ACE) inhibitors. In March 2014, a generic version became available in the United States.
Angiotensin receptor antagonists have been linked to reduced risk of AD. They act on the renin-angiotensin system, which regulates blood pressure in the body and the brain, and have been proposed to slow AD pathogenesis by controlling cerebral blood flow, protecting the cerebral microvasculature, and reducing plaque formation in the brain.
How should this medicine be used?
Telmisartan comes as a tablet to take by mouth. It is usually taken once a day with or without food. To help you remember to take telmisartan, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take telmisartan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Telmisartan tablets come in individual blister packs that can be opened by peeling back the paper layer from the foil and pushing the tablet through the foil. Do not open a blister pack until you are ready to swallow the tablet it contains.
Your doctor may start you on a low dose of telmisartan and gradually increase your dose.
Telmisartan controls high blood pressure but does not cure it. Your blood pressure may decrease during the first 2 weeks of your treatment, but it may take 4 weeks for you to notice the full benefit of telmisartan. Continue to take telmisartan even if you feel well. Do not stop taking telmisartan without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
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