USP Local Anesthetic Tetracaine HCL CAS 136-47-0 Pharmaceutical Raw Powder
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Quick Details:
Product name:Tetracaine Hydrochloride;Tetracaine HCL
Synonyms: Tetracaine HCL
CAS: 136-47-0
EINECS: 205-248-5
MF: C15H25ClN2O2
MW: 300.82
Assay:99.5% min
Melting point : 149°C
Grade : Pharmaceutical Grade
Storage temp: Refrigerator
Appearance: White Solid
Usage: Local anesthetic; Mainly used in mucosa anesthetic.The function is stronger than Procaine and Lidocaine.
COA:
| Test Items | Specification | Test Results |
| Appearance | Fine, white, crystalline, odorless powder | confirm |
| Identification | ABC in Pass | confirm |
| Solubility | Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene | confirm |
| USP Reference standards | USP Tetracaine Hydrochloride RS. USP Endotoxin RS. | confirm |
| Melting point | 145~150 degree | 146.0~147.5 degree |
| Chromatographic purity | In Pass | confirm |
| Related substance | Not more than the reference solution 0.05% | confirm |
| Heavy metals | <10ppm | confirm |
| PH | 4.5-6.5 | 5.8 |
| Residue on ignition | <0.10% | 0.05% |
| Loss on Drying | <0.5% | 0.19% |
| Assay | 98.0 -101.0% | 100.1% |
| Conclusion | Confirms USP 32 | |
Description:
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Fuction of Tetracaine Hydrochloride:
Tetracaine hydrochloride is indicated for the production of spinal anesthesia for procedures requiring two to three hours. Parenteral administration of Tetracaine hydrochloride stabilizes the neuronal membrane and prevents initiation and transmission of nerve impulses thereby effecting local anesthesia.
The onset of action is rapid, and the duration is prolonged (up to two or three hours or longer of surgical anesthesia).Tetracaine hydrochloride is detoxified by plasma esterases to aminobenzoic acid and diethylaminoethanol.
What should I watch for while using this medicine?
Do not touch, wipe or rub your eyes after application of this medicine; you could hurt the eye without feeling it. Do not try and put contact lenses in your eyes until the effect of this medicine has worn off. Follow your doctor's directions.
You should not use this medicine yourself except under the direct supervision of your doctor. This medicine should not be used for prolonged periods of time. If your condition does not improve, call your health care professional.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Protect from light. Throw away any unused medicine after the expiration date. Do not use the medicine if it is cloudy or if crystals form in it.
Product List:
| Product name | CAS NO. | Product name | CAS NO. |
| Benzocaine | 94-09-7 | Procaine | 59-46-1 |
| Hydrochloride | 129938-20-1 | Tetracaine HCl | 136-47-0 |
| Clobetasol Propionate | 25122-46-7 | L-Thyroxine | 51-48-9 |
| Finasteride | 98319-26-7 | Dydrogesterone | 152-62-5 |
| Theophylline | 58-55-9/ 5967-84-0 | Valdecoxib | 181695-72-7 |
| Procaine HCl | 51-05-8 | Lidocaine HCl | 73-78-9 |
| Lidocaine | 137-58-6 | Benzocaine HCl | 23239-88-5 |
| 119356-77-3 | L-Epinephrine hydrochloride | 55-31-2/ 329-63-5 | |
| Chloramphenicol | 56-75-7/ 2787-09-9 | Doxorubicin hydrochloride | 25316-40-9 |
| Omeprazole | 73590-58-6/ 119141-89-8 | Benzyl benzoate | 120-51-4 |
| Dutasteride | 164656-23-9 | Cyanocobalamin | 68-19-9/18195-32-9/ 13408-78-1 |
| Acetaminophen | 103-90-2 | Paromomycin | 7542-37-2 |
| Amikacin disulfate salt | 39831-55-5/ 149022-22-0 | Nitazoxanide | 55981-09-4 |
| Dexamethasone sodium phosphate | 55203-24-2/ 312-93-6 | Secnidazole | 3366-95-8 |
| Trestolone acetate | 6157-87-5 | Tinidazole | 19387-91-8 |
| Lincomycin hydrochloride | 7179-49-9 | Chlorhexidine Gluconate | 18472-51-0 |
| Clotrimazole | 23593-75-1 | 1,3-dimethyl-pentylamine hydrochloride | 105-41-9 |
| 1,3-Dimethylbutylamine hydrochloride | 71776-70-7 | 4 amino-2-Methylpentane citrate(AMP Citrate) | 71776-70-0 |
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