Clear Colorless Liquid Safe Organic Solvents CAS 96-48-0 γ Butyrolactone GBL
GBL is an important chemical raw material and intermediate for medicine, and also the intermediate of the synthesize N-methyl pyrrolidone, α -pyrrolidone, polyvinyl pyrrolidone, α -acetyl-γ -butyrolactone, methionine and the butyric acid compounds.
This product features a strong solubility, and is a good solvent for polyacrylonitrile, epoxy resin, polyvinyl butyral, polyvinyl chloride and its copolymers, and cellulose polymers. In medical industry, it is mainly used in synthesizing cyclopropylamine, etc.
Gamma butyrolactone (GBL) is a chemical compound that can be synthesized in laboratories but can also be found in unadulterated wines. On its own, gamma butyrolactone does not have any effects.Nevertheless, when it is absorbed into the blood, it is subjected to the action of lactonase enzymes. These enzymes catalyze the conversion of gamma butyrolactone into gamma hydroxybutyric acid (GHB).
As a prodrug of GHB, gamma butyrolactone is sometimes referred to as dehydrated GHB. As indicated by the term " dehydrated," GBL does not contain as much water as GHB, and is therefore more fat-loving, or lipophilic. Compared with GHB, GBL is absorbed faster when consumed with food. This causes it to produce the desired effects faster. The duration of action of gamma butyrolactone, however, is also shorter than that of its counterpart.
The effects of gamma butyrolactone are based on its property as a prodrug of GHB. GHB is similar to the naturally produced neurotransmitter called gamma aminobutyrate (GABA). GABA is produced by the brain and acts on receptors to block nerve impulses, thereby earning the label " inhibitory" neurotransmitter. The effects of GABA include relaxation, sleep, an increased feeling of well-being, decreased anxiety and decreased muscle tone. Furthermore, GABA release is associated with increased levels of growth hormone.
Appearance: Clear colorless oily liquid
Melting Point: -43.53°C
Boiling Point: 204°C @ 760 mmHg, 89°C @ 12 mmHg
Flash Point: 98°C (open cup)
Solubility: miscible with water, soluble in methanol, ethanol, acetone, ether, benzene
Additionnal data: density (15°C) 1.1286
Notes: aspect : oily hygroscopic liquid
Usage: Used as pharmaceutical intermediate, industry solvent, diluents, curing agent.
|Appearance||Colorless clear liquid||Colorless clear liquid|
|Purity (wt%, GC)||≥99.80||99.80|
|Moisture (wt%, K.F.)||≤0.03||0.020|
|Glycol (wt%, GC)||≤0.02||0.003|
|Tetrahydrofuran (wt%, GC)||≤0.03||0.024|
|Conclusion: It conforms to electron level|
1. Nutritional supplement
Due to its property of being a prodrug of GHB which increases sleep related growth hormone (GH) secretion, GBL was sold as a nutritional supplement after the scheduling of GHB, under the names Revivarant and Renewtrient in the U.S. at least until the end of 1999.
2. Recreational drug
GBL is a prodrug of GHB and its recreational use comes entirely as a result of this.To bypass GHB restriction laws, home synthesis kits were introduced to transform GBL and/or 1,4-B into GHB. FDA warning against products containing GHB and its prodrugs, such as GBL. GBL overdose can cause irrational behaviour, severe sickness, coma and death. GBL has a distinctive taste and odour, described as being comparable to stale water, synthetic melon aroma or burnt plastic. This differs significantly from GHB, which is described as having a decidedly "salty" taste.
If taken undiluted by mouth, GBL can cause esophageal and gastro-intestinal irritation. It is possible for oral ingestion of GBL to cause nausea and other similar problems, possibly more so than with GHB.
GHB has biphasic effects, a euphoric effect at low doses (the reason for the term liquid ecstasy), and a sedative effect at higher doses. As a result of this sedation it can cause unconsciousness. When combined with alcohol the increased sedation and risk of vomiting results in a high risk of fatality. Many harm reduction organisations suggest never mixing the two drugs as a result. There have been news reports of several deaths associated with GBL, usually in combination with alcohol or other depressants.
GBL has been found in extracts from samples of unadulterated wines.This finding indicates that GBL is a naturally occurring component in some wines and may be present in similar products.
The concentration detected was approximately 5 μg/mL and was easily observed using a simple extraction technique followed by GC/MS analysis. GBL can be found in cheese flavourings but typically results in a content of 0.0002% GBL in the final foodstuff.
1) GBL Magic Cleaner has a unique cleaning strength.
2) GBL is used to produce the related GHB. GHB has been classified as a Class C drug.
3) people take gamma butyrolactone (GBL) for improving sleep, athletic performance and sexual performance and pleasure.
They also take it for relieving depression and stress, promoting clear thinking, prolonging life, causing relaxation, and releasing hormone. GBL is also used to trim fat and as a body- or muscle-builder. Some people take it as a recreational drug.
Storage and transportation:
1. Storage: All products should be stored at a dry and ventilated location away from fire and other dangerous goods, and should avoid direct sunlight.
2. Transportation: During the transportation process, all containers should be free of leak, collapse,falling and damage. It should be handled lightly to prevent damage to the package. It is prohibited to be transported together with toxic and corrosive materials. In the transport process, all products should be prevented from the sun and rain and should keep away from fire, heat and high-temperature zone.Shelf life: All products have a shelf life of one year under the specified storage conditions.
The appropriate dose of gamma butyrolactone (GBL) depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for gamma butyrolactone (GBL).
Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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