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Citicoline sodium CAS 33818-15-4 for Boostering Brain White Powder
WHAT IS CITICOLINE?
Citicoline is a brain chemical that occurs naturally in the body. As a medicine, it is taken by mouth as a supplement or given by IV or as a shot.
Citicoline is used for Alzheimer's disease and other types of dementia, head trauma, cerebrovascular disease such as stroke, age-related memory loss, Parkinson's disease, attention deficit-hyperactive disorder (ADHD), and glaucoma.
Citicoline was originally developed in Japan for stroke. It was later introduced as a prescription drug in many European countries. In these countries it is now frequently prescribed for thinking problems related to circulation problems in the brain. In the US, citicoline is marketed as a dietary supplement.
Chemical name: Citicoline sodium
Appearance: white powder
Purity: over 99%
|China pharmacopoeia 2010 edition 2|
Items of analysis
|Appearance||White crystals or crystalline powders; odourless||White crystalline powder|
|Indentify||Comply with the standard||Conforms|
|Related substance||Comply with the standard||Conforms|
|Solvent Residue||Comply with the standard||Conforms|
|sterility||Comply with the standard||Conforms|
|Loss on dry||≤6.0%||3.6％|
Use as a dietary supplement:
Citicoline is available as a supplement online and in stores. It is sold in over 70 countries under a variety of brand names: Cebroton, Ceraxon, Cidilin, Citifar, Cognizin, Difosfocin, Hipercol, NeurAxon, Nicholin, Sinkron, Somazina, Synapsine, Startonyl, Trausan, etc.When taken as a supplement citicoline is hydrolyzed into choline and cytidine in the intestine.Once these cross the blood-brain barrier it is reformed into citicoline by the rate-limiting enzyme in phosphatidylcholine synthesis, CTP-phosphocholine cytidylyltransferase.
Possibly Effective for:
1. Age-related memory problems. Taking citicoline seems to help memory loss in people aged 50 to 85 years.
2. Long-term blood circulation problems in the brain (cerebrovascular diseases). There is some evidence that taking citicoline by mouth or injecting citicoline into the vein or muscle might improve memory and behavior in patients with long-term cerebrovascular diseases, such as stroke.
3. Stroke recovery. Stroke patients who take citicoline by mouth within 24 hours of having the kind of stroke that is caused by a clot (ischemic stroke) are more likely than other ischemic stroke patients to have a complete recovery within 3 months. Stroke patients who receive intravenous (IV) citicoline within 12 hours of having an ischemic stroke and daily thereafter for 7 days also have improved recovery.
The effect of citicoline on visual function has been studied in patients with glaucoma.
Mechanism of action:
The neuroprotective effects exhibited by citicoline may be due to its preservation of cardiolipin and sphingomyelin, preservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolamine, partial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity. Citicoline’s effects may also be explained by the reduction of phospholipase A2 activity.Citicoline increases phosphatidylcholine synthesis. The mechanism for this may be:
By converting 1, 2-diacylglycerol into phosphatidylcholine
Stimulating the synthesis of SAMe, which aids in membrane stabilization and reduces levels of arachidonic acid. This is especially important after an ischemia, when arachidonic acid levels are elevated.
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