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|Synonyms:||1-Oxacyclopentan-2-one;2(3H)-dihydrofuranone;Gamma Butyrolactone, 1, 4- Butyrolactone,;γ -Butyroladone,;GBL; BLO,||CAS No:||96-48-0|
|Melting Point:||-45℃||Appearance:||Colorless Transparent Liquid|
CAS 96-48-0 Australia Warehouse 99.5% Colorless transparent liquid GBL Gamma-Butyrolactone pharmaceutical intermediate
GBL is a hygroscopic colorless liquid with a weak characteristic odor which is soluble in water. GBL is a common solvent and reagent in chemistry as well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for GHB, and it is used as a recreational intoxicant with effects similar to alcohol.
GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.
GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood. Animals which lack these enzymes exhibit no effect from GBL. GBL is more lipophilic (fat soluble) than GHB, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent and faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.
Product name :Gamma-Butyrolactone,GBL
Synonyms:1-Oxacyclopentan-2-one;2(3H)-dihydrofuranone;Gamma Butyrolactone, 1, 4- Butyrolactone,;γ -Butyroladone,;GBL; BLO,
Melting point: -45℃
Appearance:Colorless transparent liquid
Usage: Used as pharmaceutical intermediate, industry solvent, diluents, curing agent.
|Appearance||Colorless clear liquid||Colorless clear liquid|
|Purity (wt%, GC)||≥99.80||99.80|
|Moisture (wt%, K.F.)||≤0.03||0.020|
|Glycol (wt%, GC)||≤0.02||0.003|
|Tetrahydrofuran (wt%, GC)||≤0.03||0.024|
|Conclusion: It conforms to electron level|
It can be converted to GHB and can increase growth hormone levels, so gamma butyrolactone was widely marketed during the 1990s as a nutritional supplement. At low doses that range from 500-1,500 milligrams, the intake of GBL or GHB can promote relaxation.
At medium doses that range from 1,000-2,500 milligrams, the resulting muscle relaxation can give a person a decreased sense of balance and decreased coordination. At high doses, a person would experience adverse effects that include nausea; vomiting; decreased breathing rate, or bradypnea; decreased heart rate, or bradycardia; and seizures. The worst outcomes are coma and death.
Used to synthesize pyrrolidone products; Used as a pharmaceutical intermediate, such as Cyclopropylamine and vitamin;Used as a pesticide intermediate, such as herbicide and plant growth regulator;Used for alkenes, alkynes extraction agent, absorbent and dispersing agent;
Used to synthesize resin as an antioxidant, plasticizer, dispersing agent, fixing agent and solvent;Used to synthesize fiber spinning solvent, coagulant, dyeing assistant and antistatic agent; Used as a raw material of color film former, electrolyte, capacitor and ink lubricant.
1) Used to produce a-pyrrolidone, 1-Methyl-2-pyrrolidinone, polyvinyl pyrrolidone, and a -Acetyl-r -butyrolactone;
2) used as anaesthetic and tranquilizer, used to produce ciprofloxacin and interferon, as the intermediate of vitamin and rolicyprine;
3) As antioxidant, plasticizer, extractant, adsorbent, dispersant, fixative and curing agent;
4) Used in battery, capacitor and development of color film.
Despite serious safety concerns and illegality, people take gamma butyrolactone for improving athletic performance, sleep, and sexual performance and pleasure.
They also take it for relieving depression and stress, prolonging life, promoting clear thinking, causing relaxation, and releasing growth hormone. GBL is also used to trim fat and as a body- or muscle-builder. Some people take it as a recreational drug.
GBL is converted to GHB shortly after entering the body. Both produce a feeling of euphoria and can reduce inhibitions and cause sleepiness.
Gamma butyrolactone is a chemical. People use it as medicine. Be careful not to confuse gamma butyrolactone (GBL) with gamma hydroxybutyrate (GHB).
Gamma-Butyrolactone + NaOH => Sodium Gamma-Hydroxy Butyrate (Na-GHB).
1) GBL Magic Cleaner has a unique cleaning strength.
2) GBL is used to produce the related GHB. GHB has been classified as a Class C drug.
3) people take gamma butyrolactone (GBL) for improving sleep, athletic performance and sexual performance and pleasure.
They also take it for relieving depression and stress, promoting clear thinking, prolonging life, causing relaxation, and releasing hormone. GBL is also used to trim fat and as a body- or muscle-builder. Some people take it as a recreational drug.
The appropriate dose of gamma butyrolactone (GBL) depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for gamma butyrolactone (GBL).
Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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