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PRL-8-53 Nootropic Research Chemical CAS 51352-87-5 Memory and Learning Enhancer
CAS number: 51352-87-5
English name: PRL-8-53
Synonyms: PRL-8-53;PRL-8053;PRL-8-53 (hydrochloride);Methyl 3-(2-(benzyl(methyl);Methyl 3-(2-(benzyl(Methyl)aMino)ethyl)benzoate hydrochloride;m-[2-(Benzylmethylamino)ethyl]benzoic acid methyl ester hydrochloride;3-(2-Benzyl(methyl)aminoethyl)benzoic acid methyl ester hydrochloride;Benzoic acid, 3-(2-(Methyl(phenylMethyl)aMino)ethyl)-, Methyl ester, hydrochloride
Appearance: White crystal powder
Benefits: Nootropic, memory improvement
Dosage: 5mg or according to bodyweight
Package: 500g/bag, 1kg/bag, 5kg/bag
4 th , July. 2016
3 rd , July. 2018
Items of analysis
|Appearance||Off white solid powder||Conform|
|Identification||Conform with NMR||Conforms|
|Loss on Drying||≤0.50%||0.23%|
|Residue on ignition||≤1.0%||0.28%|
|Heavy metals||NMT 20PPM||Conforms|
PRL-8-53 is a nootropic research chemical derived from benzoic acid and phenylmethylamine (Benzylamine) that has been shown to act as a hypermnesic drug in humans; it was first synthesized by medical chemistry professor Nikolaus Hansl at Creighton University in the 1970s as part of his work on amino ethyl meta benzoic acid esters.
Mechanism of actions of PRL-8-53:
How does PRL-8-5-3 work? The exact mode of action of PRL-8-53 remains not yet known. According to the Wikipedia introduction, PRL-8-53 does not display stimulant properties, and does not potentiate dextroamphetamine. It displays cholinergic properties, and potentiates dopamine while partially inhibiting serotonin. PRL-8-53 reverses the catatonic and ptotic effects of reserpine.
Dr. Hansl stated in his PRL-8-53 patent that PRL-8-53 functions through enhancing the response of the brain towards acetylcholine. If you want to know more about the detailed choline mechanism, you may read more information on our product page like alpha gpc, citicoline (CDP choline), etc. In his study, he suggested that it has cholinergic mechanisms. To some extent, it has been said to act as a dopamine agonist. It is also said to potentiate the release of dopamine whilst partially inhibit the release of serotonin - all of which helps in improving learning motivation among users.
The benefits of PRL-8-53 aren’t fully known, but it is generally considered to be a memory and learning enhancer. In the lone study with rats, taking PRL-8-53 120 - 150 minutes before a cognitive test helped drastically. Memory was tested at 24 hours after dosing and 96 hours with positive results compared to a placebo.
Within these tests, some of the test performance improvements were in the range of 80 - 100+%, which suggests significant potential.
The study separated the analysis of memory and “working memory”, which showed less improvement, but still notable.
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Nootropics Drug List:
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