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Healthy Bodybuilding Fat Loss Supplements AICAR CAS 2627-69-2 Pharmaceutical Grade

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Good quality Testosterone Anabolic Steroid for sales
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Healthy Bodybuilding Fat Loss Supplements AICAR CAS 2627-69-2 Pharmaceutical Grade

China Healthy Bodybuilding Fat Loss Supplements AICAR CAS 2627-69-2 Pharmaceutical Grade supplier
Healthy Bodybuilding Fat Loss Supplements AICAR CAS 2627-69-2 Pharmaceutical Grade supplier Healthy Bodybuilding Fat Loss Supplements AICAR CAS 2627-69-2 Pharmaceutical Grade supplier Healthy Bodybuilding Fat Loss Supplements AICAR CAS 2627-69-2 Pharmaceutical Grade supplier

Large Image :  Healthy Bodybuilding Fat Loss Supplements AICAR CAS 2627-69-2 Pharmaceutical Grade

Product Details:

Place of Origin: China
Brand Name: LSW
Certification: GMP, ISO9001, USP, KOSHER
Model Number: 2627-69-2

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: Discreet disguised package or as required
Delivery Time: 3~7 working days
Payment Terms: Western Union, Moneygram, Bitcoin and Bank Wire Transfer
Supply Ability: 5000kg/week
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Detailed Product Description
Appearance: White Powder Shelf Life: 2 Years
Usage: Fat Burning Steroids Grade: Pharmaceutical Grade
Purity: 99% CAS Number: 2627-69-2

CAS: 2627-69-2 White Powder Healthy Fat Burning Steroids AICAR for Weight Loss

 

Discription:

 

Acadesine (INN), also known as 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.


Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery. Schering began patient enrollment in phase III studies in May, 2009. The trial was terminated in late 2010 based on an interim futility analysis.


Acadesine (chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in.


Quick Details :

 

Product Name: AICAR/ Acadesine
Full name: 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside
Alias: AICA Riboside; Acadesine
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Appearance: White powder
Purity: 99.8%
Usage: Glucose uptake stimulant; AMPK activator; AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

 

 

COA:

 

 

Product name

 

AICAR(Acadesine )

 

CAS No.

 

2627-69-2

 

Outer Packing

 

1KG

 

Items of analysis

 

Specification

 

Results

 

Description

 

White powder, or Off-White Solid powder

 

Off-White Powder

 

Identification

 

H-NMR LCMS

 

Conform

 

Melting point

 

215 - 216 ℃

 

Complies

 

Loss on drying

 

≤0.5 %

 

0.18%

 

Heavy metals

 

≤10ppm

 

Conform

 

Total impurities

 

≤3.0 %

 

0.75%

 

Assay

 

(HPLC) > 98.0 %

 

99.10%

 

Conclusion

 

Qualified

 

 

 

How it works ?

 

Acadesine is an analog of adenosine that enters cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia.In cardiac myocytes, acadesine is phosphorylated to AICAR to activate AMPK without changing the levels of the nucleotides. AICAR is able to enter the de novo synthesis pathway for adenosine synthesis to inhibit adenosine deaminase causing an increase in ATP levels and adenosine levels.

 

Application:

 

Sarms AICAR/ Acadesine powder help burn fat and sustain output in activity
AICAR is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in.

 

Aicar (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/ inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

 

Function:

 

AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

 

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

 

DOSAGE:

 

Dosages range from 150 milligrams (mg) per day (if stacked with GW), up to 500mg a day when used solo. Considering the fact that each bottle typically comes in 50mg dosages, that is quite expensive, as already mentioned above. Economically, it makes most sense to run AICAR during the 4 weeks leading up to your competition.

 

 

 

Our Advantage:

 

High quality with competitive price:


1) Standard: Enterprise Standard


2) All Purity:>=99%


3) We are manufacturer and can provide high quality products with factory price.

 

Fast and safe delivery:


1) Parcel can be sent out in 24 hours after payment. Tracking number available.


2) Secure and discreet shipment. Various transportation methods for your choice.


3) Customs pass rate: >=99%


4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

 

We have clients throughout the world:


1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.


2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.


3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

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Our Advantage:

 

High quality with competitive price:

1) Standard: Enterprise Standard

2) All Purity:>=99%

3) We are manufacturer and can provide high quality products with factory price.

 

Fast and safe delivery:

1) Parcel can be sent out in 24 hours after payment. Tracking number available.
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate: >=99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.


We have clients throughout the world:

1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.

2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.

3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

Healthy Bodybuilding Fat Loss Supplements AICAR CAS 2627-69-2 Pharmaceutical Grade

 

If you have any question,you can feel free to contact me.

 

Whatsapp(Skype):+8618872220662  

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