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|Appearance:||White Powder||Assay:||Over 99%|
|Usage:||Treating Obesity||CAS Number:||96829-58-2|
CAS: 96829-58-2 Anti Obesity Orlistat fermentative Form Raw Powder
Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. In the intestine, an enzyme called lipase (produced primarily by the pancreas) breaks apart fat in food so that it can be absorbed into the body. Orlistat blocks the action of lipase and thereby prevents the breakup and absorption of fat. Orlistat blocks absorption of about 25% of the fat in a meal. The unabsorbed fat is excreted in the stool.
Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug.
Dietary fats need to be broken down into smaller pieces before the body can absorb them. Orlistat works by blocking the enzyme that breaks down fats in your diet. This undigested fat then passes out of your body in your bowel movement. Orlistat does not block the absorption of calories from sugar and other non-fat foods, so you still need to restrict your total intake of calories.
Chemical Names: Orlistat; 96829-58-2; Tetrahydrolipstatin; Xenical; Alli; Orlipastat More...
Molecular Formula: C29H53NO5
Molecular Weight: 495.745 g/mol
Appearance: white powder
Usage: Treating obesity
|Appearance||white or almost white crystalline powder,smell less|
|Identification||The result of HPLC is consisitent to the reference one. The result of IR is consisitent to the reference one.|
|Related Substances||≤ 0.5%|
|Total impurity||≤ 1.0%|
|Single impurity||≤ 0.1%|
|Residual on Ignition||≤0.1%|
|Heavy Metal||≤ 20ppm|
|Purity||≤ 99.0% ~ 99.9%|
The effectiveness of orlistat in promoting weight loss is definite, though modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2-3 kilograms (4.4-6.6 lb) more than those not taking the drug over the course of a year.Orlistat also modestly reduces blood pressure, and appears to prevent the onset of type 2 diabetes, whether due to weight loss itself or to other effects; in a large randomized controlled trial, orlistat was found to reduce the incidence of diabetes by nearly 40% in obese people.
Orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). In the United States and the European Union, orlistat is available for sale without a prescription. Generic formulations of orlistat are available in some countries.
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Weight Loss Drugs
Intermediates & Fine Chemicals;
Treatment of obesity
|Product name||CAS number|
|Sodium octadecyl fumarate||4070-80-8|
|Tirofiban hydrochloride monohydrate||150915-40-5|
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