Quick Details:

CAS No.: 137-58-6
EINECS: 205-302-8
Molecular Formula: C14H22N2O
Molecular Weight: 234.34 g/mol
Density: 1.026 g/cm3
Melting Point: 66-69 ° C
Boiling Point: 350.8 ° C at 760 mmHg
Flash Point: 166 ° C
Application: It is a common local anesthetic and antiarrhythmic drug.
Solubility: Soluble in water

Product description:

Local Anesthetic Drugs Lidocaine, also known as xylocaine and lignocaine , is a medication used to numb tissue in a specific area and to treat ventricular tachycardia . It can also be used for nerve blocks . Lidocaine mixed with a small amount of epinephrine is available to allow larger doses to be used as numbing and to make it last longer . When used as an injectable it typically begins working within four minutes and lasts for half an hour to three hours . Lidocaine may also be applied directly to the skin for numbing.

Common side effects with intravenous use include sleepiness, muscle twitching , confusion , changes in vision , numbness , tingling, and vomiting . It can cause low blood pressure and an irregular heart rate.There are concerns that injecting it into a joint can cause problems with the cartilage . It appears to be generally safe for use in pregnancy . A lower dose may be required in those with liver problems . It is generally safe to use in those allergic to tetracaine or benzocaine . Lidocaine is an antiarrhythmic medication of the class Ib type . Lidocaine works by blocking sodium channels and thus decreasing the rate of contractions of the heart . When used locally as a numbing agent, local neurons cannot signal the brain.

Local Anesthetic Drugs Lidocain was discovered in 1946 and went on sale in 1948 . It is on the WHO Model List of Essential Medicines , the most important medications needed in a basic healthcare system . It is available as a generic medication and is not very expensive . The wholesale cost in the developing world in 2014 was US$0.45 to $1.05 wholesale per 20ml vial of medication .

Applications:

The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such asbupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action. Epinephrine vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful.Lidocaine drops can be used on the eyes for short ophthalmic procedures.

Topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though not enough study evidence exists to recommend it as a first-line treatment.ntravenous lidocaine also has uses as a temporary fix for tinnitus. Although not completely curing the disorder, it has been shown to reduce the effects by around two-thirds.

Lidocaine is also the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

Inhaled lidocaine can be used as an antitussive (cough suppressor) acting peripherally to reduce the cough reflex. This application can be implemented as a safety and comfort measure for patients who have to be intubated, as it reduces the incidence of coughing and any tracheal damage it might cause when emerging from anesthesia.

Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.

COA:

Before use Lidocaine, you should care

Before using lidocaine, tell your doctor or pharmacist if you are allergic; or other amide anesthetics (eg bupivacaine, prilocaine); or if you have any other allergies. This product may contain inactive ingredients that can cause allergic reactions or other problems. Talk to your pharmacist more details.

Before using this medication, tell your doctor or pharmacist your history, especially: lidocaine use the area of skin / infection, heart disease, liver disease.

When children use this drug, it is recommended that they may be more sensitive to the side effects of the drug.

During pregnancy, this medicine is used only when it is clearly needed. Talk to your doctor about risks and benefits ...

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