Over 99% Purity White Nootropics drug Powder Nicotinamide ribose CAS 1341-23-7
Description:
Nicotinamide Riboside is White Crystalline Powder and found in milk. This product has become more and more popular because of various scientific studies that prove its ability to prevention of overweight and obesity. Researchers have found that this ingredient will boost your metabolism, increasing the rate at which your body burns fat and calories. And has an effective diabetes preventive.
Nicotinamide is a water-soluble vitamin, white crystalline powder, odorless or almost odorless, bitter, soluble in water or ethanol, soluble in glycerol, widely distributed in the body, in the bio-oxidative respiratory chain The role of hydrogen transport can promote the biological oxidation process and tissue metabolism.
Quick details:
Product Name:NICOTINAMIDE RIBOSIDE
Synonyms:Nicotiamide Riboside;Nicotinamide ribonucleoside;NICOTINAMIDE RIBOSIDE(R)-5-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)cyclohexa-1,3-dienecarboxamide;NR(Nicotinamide Riboside);NICOTINAMIDE RIBOSIDE;Nicotinamide Ribose;1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridine-5-carboxamide;nicotinamide-beta-riboside
CAS:1341-23-7
MF:C11H16N2O5
MW:256.26
Appearance: white powder
Purity: over 99%
Drug class: Nootropics drug
COA:
| Product name |
Nicotinamide Riboside (NR) |
| CAS No. |
1341-23-7 |
Outer Packing |
1kg/ |
| Standard adopted |
2017.10.20 |
Shelf life |
2 years |
| Items of analysis |
Specification |
Results |
| Appearance |
pale yellow to white powder |
pale yellow powder |
| NR Purity by HPLC |
NLT 98% |
98.10% |
| NR Content by HPLC |
NLT 20% |
27.80% |
| PH Value |
5-7 |
6.4 |
| Ash |
≤0.6% |
0.22% |
| Conclusion |
Qualified |
How Nicotinamide Riboside Works
There’s basically three important pieces of this puzzle. NAD+, Nicotinamine Riboside (NR) and Sirtuin Enzymes, all of which relate to the nucleus, mitochondria, and most importantly, the communication between the two in every cell.
It all begins with the mitochondria. Mitochondria have long been known as the “power houses” of our cells, as they are responsible for energy production in each specific cell; and therefore, throughout our entire body.
The nucleus, on the other hand, is the controller of the cell. The nucleus ensures that everything inside of the cell is going well, that all of the “employees” at “Cell Corporation” are doing their jobs effectively.
The problem, as Sinclair and Cantó, et al. discovered, occurs when communication between these two important organelles breaks down. When that happens, the cells begin to suffer the effects of age, producing less energy and not working as efficiently as possible. This failure manifests itself in aging - both in the skin, and in the skeletal and muscle structure.
That is to say, when the nucleus and mitochondria don’t communicate properly, everything falls apart.
This is where the three puzzle pieces fit in. This communication is promoted by an enzyme called Sirutin 1, or SIRT1. This enzyme is responsible, essentially, for ensuring outside molecules don’t interrupt the traffic between the nucleus and the cell wall.
SIRT1, in turn, is activated by a chemical called NAD+. NAD+ is what’s known as a co-substrate, which is basically an activator - a compound that ensures the activation of a certain molecule. NAD+ is the most important part of this whole equation.
Luckily for us, NAD+ is a naturally occurring molecule in our body. Without it, our cells would die quickly. Unluckily, NAD+ levels decline as we age, resulting in wrinkles, bone deterioration, and muscle decline.
This is where Sinclair and Cantó, et al.’s research comes in. They identified a new vitamin that can stoke the production of NAD+ - without the side effects of other NAD+ precursors like Nicotinic Acid, which causes severe flushing.
This NAD+ producer is nicotinamide riboside. In both studies, the mice who were supplemented with NR showed powerful anti-aging effects, metabolic energy increases and improvements in cell repair and upkeep. This suggests that supplementation with this new vitamin is a possible key to halting the effects of aging.
Even more interesting, Cantó, et al. suggest that NR can also be used to “ameliorate metabolic and age-related disorders”. This can be applied to problems that arise from our metabolism and aging problems, like arthritis and type 2 diabetes.
It is important to note that these two studies have only been used on mice. There is a bit of a gap as far humans go. Specifically, the amount of NR necessary to induce a change is, at the current moment, nebulous.
Vitamin NR Dosage
Getting the vitamin NR dosage correct can help avoid nicotinamide riboside side effects as well. Most of the studies are in the thousands of milligrams per kilogram of bodyweight, but the suggested NR supplement dose is 1 - 200 mg per day.
There are plenty of anecdotal reports of doses up to 600 mg per day, which can increase mental energy and focus, but these are neither common nor recommended for first time users. It’s best to take niagen within the 1 - 200 mg per day dose range.
Health Benefits of Nicotinamide Riboside:
1) Nicotinamide Riboside Helps Muscle Function
NR administration rapidly restored muscle mass. Additionally, it preserved muscle NAD levels and exercise capacity in older mice, helping maintain muscle mass and function.
Mitochondrial myopathy is a disease where the mitochondria in muscle cells are damaged. It can cause muscle weakness and other problems.
Oral administration of NR in mice delayed myopathy progression by preventing mitochondrial abnormalities. NR supplementation reduced NAD+ consumption, which improved mitochondrial function.
NR also stimulated mitochondrial unfolded protein response, which protects against mitochondrial disease.
2) Nicotinamide Riboside Helps Fight Against Cancer
NR can be used to generally limit tumor growth in mice with high levels of oxidative stress.
Low levels of NAD+ synthesis can cause DNA damage. NR supplementation increases NAD+ levels, which can help protect against DNA damage, oxidative damage, and tumor progression .
3) Nicotinamide Riboside Reduces Diabetic Symptoms
In prediabetic mice, NR supplementation improved glucose tolerance, reduced weight gain, and reduced liver damage. In Type 2 diabetic mice, NR greatly reduced blood glucose and protected against diabetic nerve problems.
4) Nicotinamide Riboside Protects the Brain
Proper NAD metabolism can help protect the brain. NR protects the nerve cells in the brain by activating the SIRT3 (R) and PGC1a (R) pathways.
NR can also delay axonal degeneration, which can preserve nerve cells. Supplementation stimulates the NAD pathways and helps prevent degeneration in the brain.
NR improved cognitive function, and slowed progression of Alzheimer’s disease in mice given NR for 3 months.
5) Nicotinamide Riboside Protects the Liver
Oral administration of NR naturally increases NAD in the body, which helps protect the liver.
NR stopped fat accumulation, lowered oxidative stress, prevented inflammation, and improved insulin sensitivity in the liver of mice.
6) Nicotinamide Riboside Prevents Hearing Loss
Administration of NR, even after noise exposure, prevents noise-induced hearing loss in mice. It reduces degeneration of nerve cells caused by noise exposure.
SIRT3 mediates these effects.
7) Nicotinamide Riboside Increases Metabolism
In mice, supplementation of NR (400mg/kg) increased NAD+ levels in muscles, which increased their energy use and metabolism.
8) Nicotinamide Riboside May Help with Weight Loss
NR may increase enzymes involved in burning fat (sirtuin enzymes), and energy expenditure thus helping with weight loss.
9) Nicotinamide Riboside Increases Longevity
NR increases the amount of NAD in the body, which can help reprogram dysfunctional cells. These combined effects can help increase longevity in mammals.
NR induced the mitochondrial unfolded protein response and synthesis of prohibitin proteins, and this rejuvenated stem cells in aged mice.
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