White Nootropics Memory Improving Raw Sarm Powder DM 235/Sunifiram CAS 314728-85-3
Description:
Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232).
This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation. Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation. This compound is known as an AMPAkine due to exerting most of its actions via the AMPA receptor (one of the three main subsets of glutamate receptors, alongside NDMA and kainate).
This enhancement of AMPA function seems to also rely on enhancing signalling via the Glycine binding site of NMDA receptors, although one minimal signalling goes through the NMDA receptor then the benefits on AMPA receptors seem dose-dependent.
Sunifiram is one of the newest nootropics on the market showing very promising initial results. It falls into the ampakine family of nootropic supplements because it is an AMPA agonist.Some reviews have suggested that it works similarly to Piracetam but it is over 1000 times more potent than Piracetam for the same dosage.
Sunifiram is highly effective at boosting memory function as well as attention span, learning, decision making and alertness.A lot of initial reviews and user experiences suggest that Sunifiram could become one of the most popular nootropic study aids for improving concentration.
Sunifiram has a similar chemical structure to Piracetam but initial studies show that it is significantly more potent than this widely used racetam.Sunifiram so far shows very positive results as memory enhancer and it is currently being investigated for potential treatment of Alzheimer's and other diseases related to cognitive decline.
User reviews and Sunifiram logs point to the fact that this supplement makes information recall much easier and helps you think more clearly. Sunifiram is being compared to Noopept quite a bit because of their similar potency levels.Initial observations suggest that Sunifiram is better as a memory booster while Noopept might have an edge on increasing focus and alertness.
Quick details:
Product Name: Sunifiram/ DM-235
Synonyms: Piperazine, 1-benzoyl-4-(1-oxopropyl)-; SunifiraM; 1-(4-Benzoyl-1-piperazinyl)-1-propanone; 1-Benzoyl-4-(1-oxopropyl)-piperazine; 1-(4-Benzoylpiperazin-1-yl)propan-1-one; 1-Benzoyl-4-propanoylpiperazine
CAS: 314728-85-3
MF: C14H18N2O2
MW: 246.30492
Appearance: White powder
Purity: 99.32%
Shelf life: 2 years
Standard: In-house Standard
Usage: For the treatment of Alzheimers Dementia, Cognition Disorder, Neurologic Drugs,Senile Dementia, Acetylcholine Release Enhancers.
The COA of Sunifiram:
| Items of Analysis |
Requirements |
Results |
| Appearance |
Off-white to white powder |
Conforms |
| Loss on drying |
≤1.0% |
0.6% |
| Heavy metal |
≤10ppm |
Conforms |
| Water |
≤0.5% |
0.3% |
| Purity(HPLC) |
≥99% |
99.47% |
| Residue on ingnition |
≤0.3% |
0.05% |
| Conclusion |
The product conforms to in House Standard |
| Packing |
Pack in two layers plastic-bag. |
| Storage |
Store in a well-closed place with constant low temperature and no direct sun light. |
| Shelf life |
2 years when properly stored. |
Applications of Sunifiram/ DM-235:
Sunifiram (DM-235) is a piperazine derived research chemical which has anti-amnesiac effects in animal studies with significantly higher potency than piracetam. Sunifiram is a molecular simplification of unifiram. Based on in vitro and animal studies, it appears that sunifiram acts via AMPA-receptor activation.
Sunifiram operates by activating AMPA receptors; that is, the receptors that are responsible for the mediation of synaptic transmission in the central nervous system. Its mechanics also increases phosphorylation of AMPAR and NMDAR through protein kinase activation, which in turn enhances long-term potentiation - that is, an enhancement in signal transmission between two neurons resulting from simultaneous stimulation.
The kinase activation that is influenced by Sunifiram also improves cognitive defects. Additionally, Sunifiram works in the cerebral cortex of animal test subjects by assisting in the release of acetylcholine, the organic molecule that acts as a neurotransmitter in a host of various organisms. These operational mechanisms enable Sunifiram to exert anti-amnesiac properties.
Sunifiram(DM-235) Function:
Sunifiram activates AMPA-mediated neurotransmission.
SunifiramEnhancing LTP in a bell-shaped dose-response relationship.
Sunifiram aids in the release of acetylcholine in the cerebral cortex.
Sunifiram increases energy levels, allowing users to feel more motivated and eliminate
Sunifiram increase Levels of concentration increase, and users feel less distracted by external stimuli.
Sunifiram enhances long-term potentiation, which is the forming of new connections regarding memory storage.
Sunifiram has some anxiolytic benefits. Feeling more relaxed is beneficial when trying to focus.
Dosage and How to Take?
Sunifiram is incredibly concentrated compared even to the strongest racetams like Pramiracetam. You will see positive effects from a dosage as small as 4 mg though many people typically take between 5-8 mg at a time. A Sunifiram dose of 10 mg is more likely to cause a stimulant effect similar to Adderall.
Taking a 10 mg Sunifiram dosing is not toxic and not likely to cause serious negative side effects, however you may experience increased body temperature and perspiration. You should start with a half dose of 3 mg for your first week or so of taking this ampakine nootropic and then only increase the dosage if you feel comfortable.
Sunifiram Effects
Sunifiram works very similarly to other racetams by stimulating many of the same receptors just in different ways. The primary effect of taking Sunifiram is stimulation of AMPA receptors (hence which this drug is considered an AMPAkine). In clinical trials, patients given the AMPA antagonist NBQX and then given Sunifiram saw increased AMPA receptor activity. AMPA receptors are responsible for how much glutamate is produced in the brain. Glutamate is perhaps the most important neurotransmitter in the brain, responsible for communicating excitatory transmissions, forming connections between synapses, and for regulating brain cell survival.
Benefits of Sunifiram:
Based on research and user reviews, the benefits are plentiful. There is a range of benefits, all relating to cognitive enhancement. This is why Sunifiram has been popular amongst students. It increase one's ability to focus, as well as recall information.
Sunifiram increases energy levels, allowing users to feel more motivated and eliminate procrastination. Users report being more goal-oriented, wanting to get things done. This is popular amongst students or employees, as it does not create the negative side-effects like Ritalin or Adderall do. This increase in energy levels and attention span, are the result of increased glutamate activity.
Levels of concentration increase, and users feel less distracted by external stimuli. Once again, this makes it effective when studying. Certain employees would also benefit, especially in such a competitive career world.
There have been a lot of studies conducted regarding memory. Most benefits are seen regarding short-term memory or working memory. The level of recall dramatically increases, as some users have reported hearing information once and recalling it hours later. Early research showed that Sunifiram also enhances long-term potentiation, which is the forming of new connections regarding memory storage.
Levels of anxiety are reduced, as Sunifiram has some anxiolytic benefits. Feeling more relaxed is beneficial when trying to focus.
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Compound 7P;
2-[(2-methoxyphenyl
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