Safe Local Anesthetic 5875-06-9 Proparacaine Hydrochloride HCL for Anti-paining Anesthetic Anodyne
Quick details:
Product Name:Proparacaine hydrochloride
Other Name:Proparacaine Hcl
Chemoical Name:3-amino-4-propoxybenzoicacid2-(diethylamino)ethylesterhydrochloride
CAS:5875-06-9
MF:C16H27ClN2O3
MW:330.85
EINECS:227-541-7
Assay:99% min
Aooearence:White powder
Purpose:Local anesthetic drug
Description:
Proparacaine Hydrochloride Ophthalmic Solution is a rapid acting local anesthetic suitable for ophthalmic use. With a single drop, the onset of anesthesia begins within 30 seconds and persists for 15 minutes or longer.
The main site of anesthetic action is the nerve cell membrane where proparacaine interferes with the large transient increase in the membrane permeability to sodium ions that is normally produced by a slight depolarization of the membrane. As the anesthetic action progressively develops in a nerve, the threshold for electrical stimulation gradually increases and the safety factor for conduction decreases; when this action is sufficiently well developed, block of conduction is produced.
The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability by closing the pores through which the ions migrate in the lipid layer of the nerve cell membrane. This limitation prevents the fundamental change necessary for the generation of the action potential.
Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice. Representative ophthalmic procedures in which the preparation provides good local anesthesia include measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures from the cornea, conjunctival scraping in diagnosis and gonioscopic examination; it is also indicated for use as a topical anesthetic prior to surgical operations such as cataract extraction.
Applications:
Proparacaine hydrochloride and tetracaine are also indicated to produce local anesthesia prior to surgical procedures such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics.
Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solutionenters the eye through the incision.
COA:
| Items of analysis |
Specification |
Results |
| appearance |
Off White to white powder |
Off White powder |
| Loss on drying |
Less than 0.5% |
0.09% |
| PH |
5.7-6.4 |
6.0 |
| Heavy metals |
Less than 20ppm |
Less than 20ppm |
| Residual on ignition |
Less than 0.15% |
0.08% |
| Related substances |
Less than 1.5% |
1.2% |
| Assay |
98-102% |
98.63% |
| Conclusion |
Qualified |
Proparacaine hydrochloride medical use :
1. Acute pain
Acute pain may occur due to trauma, surgery, infection, disruption of blood circulation or many other conditions in which there is tissue injury. Buy Proparacaine HCl on google.com ,please contact Aimee . In a medical setting it is usually desirable to alleviate pain when its warning function is no longer needed. Besides improving patient comfort, pain therapy can also reduce harmful physiological consequences of untreated pain.
Acute pain can often be managed using analgesics. However, conduction anesthesia may be preferable because of superior pain control and fewer side effects. For purposes of pain therapy, local anesthetic drugs are often given by repeated injection or continuous infusion through a catheter. Low doses of local anesthetic drugs can be sufficient so that muscle weakness does not occur and patients may be mobilized. Guangzhou Huao Chemical Co.,Ltd is a big supplier in China for Anabolic steroid powder ,peptides ,pharmaceutical raw materials ,welcome to your inquiry ! We will provide professional services and good price for you .
Some typical uses of conduction anesthesia for acute pain are:
Labor pain (epidural anesthesia, pudendal nerve blocks)
Postoperative pain (peripheral nerve blocks, epidural anesthesia)
Trauma (peripheral nerve blocks, intravenous regional anesthesia, epidural anesthesia)
2. Chronic pain
Chronic pain is a complex and often serious condition that requires diagnosis and treatment by an expert in pain medicine. Local anesthetics can be applied repeatedly or continuously for prolonged periods to relieve chronic pain, usually in combination with medication such as opioids, NSAIDs, and anticonvulsants.
3. Surgery
Virtually every part of the body can be anesthetized using conduction anesthesia. However, only a limited number of techniques are in common clinical use. Sometimes conduction anesthesia is combined with general anesthesia or sedation for the patient's comfort and ease of surgery.
4. Other uses
Topical anesthesia, in the form of lidocaine/prilocaine (EMLA) is most commonly used to enable relatively painless venipuncture (blood collection) and placement ofintravenous cannulae. It may also be suitable for other kinds of punctures such as ascites drainage and amniocentesis.
Surface anesthesia also facilitates some endoscopic procedures such as bronchoscopy (visualization of the lower airways) or cystoscopy (visualization of the inner surface of the bladder).
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