99% Purity Local Anesthetic Prilocaine Propitocaine Hydrochloride Citanest CAS 1786-81-8
Synonyms: Propitocaine hydrochloride; 2-(Propylamino)-o-propionotoluidide hydrochloride
Packing: 25kg/cardboard drum
Character: White Solid. mp 168-170℃.
Usage: Anesthetic (local).
Prilocaine HCl Description :
Prilocaine HCl a local anesthetic agent of the amide family, used for nerve block, epidural, and regional anesthesia. It is not used for spinal or topical anesthesia.
Prilocaine hydrochloride is about half as toxic as lidocaine but, because methemoglobinemia is a possible reaction to its administration, is not used for patients with hypoxic conditions of any kind.
Prilocaine Hydrochloride is an FDA approved amino amide type local anesthetic. It is primarily used as a nerve block in dental surgery in the injectable form.
Prilocaine Hydrochloride is also used in topical anesthetic creams. It's often combined with Lidocaine.
Eutectic Mixture of Local Anesthetics (EMLA) containing 5% lidocaine and prilocaine in a cream was found
to give effective topical analgesia in normal and diseased skin, making it useful for superficial surgery and
various other clinical procedures. To be effective, an adequate amount must be applied under occlusion
and at the right time before the intervention.
Propitocaine hydrochloride is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren. In its injectable form, it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used forintravenous regional anaesthesia. In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue.
The ester can be hydrolysed in plasma by the enzyme pseudocholinesterase into PARA-aminobenzoic acid. Amide is stable for longer acting and more systemic distribution. Ester types include Procaine (Novocain), Chloroprocaine (Nesacaine), Tetracaine (Pontocaine), Benzocaine, Tetracaine. Amide types include Lidocaine (Xylocaine), Mepivacaine(Carbocaine), Prilocaine (Citanest), Bupivacaine (Marcaine), Etidocaine (Duranest).
Propitocaine hydrochloride Specification
||134.3 ° C
||168-170 ° C
||2.05E-05mmHg at 25 ° C
||361.6 ° C at 760 mmHg
|Loss on drying
||66-69 ° C
||Pharmaceutical raw materials
||White crystalline powder, odorless, a little bitter
||Store in sealed containers at cool & dry place. Keep away from light, moisture
Praca is a local anesthetic of amino amide. Prilocaine is commonly used in dentistry. Placaine is also often used in combination with lidocaine for skin anesthesia (lidocaine or EMLA) for the treatment of paresthesia and other diseases.
Local anesthesia is a substance that causes sensory loss only in its application without affecting consciousness. Most local anesthetic structures have an amino ester or aminoamide group attached to a hydrophilic (secondary or tertiary amine).
The ester can be hydrolyzed into the plasma in the form of PARA-aminobenzoic acid by the enzyme base esterase. Amides are stable for long and more systematic distributions. Esters include prochlorocene, Novos, Nesacaine, Pontocaine, Benzocaine, tetracaine. Amides include sicaine, cabbaine, Citanest, Bouaine (Marcaine), Etidocaine (Duranest).
The most recommended dose of Placaine HCL
Prilocaine HCL is used in children
Since this is due to age and weight, it is difficult to recommend the maximum dose of any drug for children. For children with normal lean body weight and normal physical development for less than 10 years, the maximum dose can be determined by applying standard pediatric drug preparations (eg, Clark rule). For example, according to the Clark rule, 5-year-old children weigh 50 pounds, according to Clark rules, acetic acid dose should not exceed 150 to 200mg (6.6 to 8.8mg / kg or 3 to 4mg / lb body weight)
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Store in cool and dry area and keep away from direct sunlight.oC
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