High Purity White Local Anesthetic Powder Lidocaine Base / Xylocaine for Pain Killer CAS 137-58-6
Description:
Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.
Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated.
Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.
Lidocaine for infiltration anesthesia, epidural anesthesia, local anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the side effects of lidocaine poisoning, can join anesthesia adrenaline.
Quick details:
Name:Lidocaine Base
Synonyms: Antrolin; Cuivasil; Dalcaine; ELA-Max; Esracaine; Isicaine; Jetocaine; Leostesin; Lidocadren; Lidoderm; Linisol
CAS: 137-58-6
Formula: C14H22N2O
Molecular Weight: 234.34
EINECS: 205-302-8
Assay: 99.0~101.0%
Appearance: White crystalline powder
Package: 25kg/drum
Density: 1.026 g/cm3
COA:
| Product name |
Lidocaine |
| Appearance |
White powder |
| Absorbance |
≤0.30% |
Conform |
| Specific Rotation |
+39°~ +43° |
+40.2° |
| Chromatography Purity |
Conform |
Conform |
| 17α-Isomer |
≤0.50% |
0.38% |
| Organic Volatile Impurities |
Conform |
Conform |
| Loss On Drying |
≤0.50% |
0.27% |
| Residue On Ignition |
≤0.10% |
0.015% |
| Assay |
97~101% |
99.5% |
Applications
The efficacy of lidocaine as a local anesthetic is characterized by rapid onset and mid-term efficacy. Thus, lidocaine is suitable for osmotic, obstructive and topical anesthesia. Long-acting drugs such as bupivacaine are sometimes superior to dural and epidural anesthesia; while lidocaine has the advantage of rapid onset.
Adrenaline vasoconstriction arteries, reducing bleeding and delaying the absorption of lidocaine, almost doubling the duration of anesthesia. For surface anesthesia, several available formulations may be used. For endoscopy, before intubation. The pH of the buffered lidocaine makes the local freezing less painful. Lidocaine eye drops can be used for eyes for short term ophthalmic surgery.
The relative insensitivity to lidocaine is hereditary. In relatively hypoallergenic hypersensitivity, the relative insensitivity to lidocaine has been described in people with attention deficit hyperactivity disorder. In dental anesthesia, due to the unexpected location of the nerves, anatomically may be relatively insensitive to lidocaine. Some patients with Ehlers-Danlos syndrome are insensitive to lidocaine.
Lidocaine and ethanol, ammonia and acetic acid have also been shown to be effective in treating jellyfish stings, disrupting the affected areas and preventing further nematode bleeding.
Functions & Traits
The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action.
Epinephrine (adrenaline) vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful. Lidocaine drops can be used on the eyes for short ophthalmic procedures.
Relative insensitivity to lidocaine is genetic. In hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. Some people with Ehlers-Danlos syndrome are insensitive to lidocaine.
Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.
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