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Nootropics drug Nicotinamide Riboside CAS 1341-23-7 White Powder
Chemical name: NICOTINAMIDE RIBOSIDE
Appearance: white powder
Purity: over 99%
Drug class: Nootropics drug
Nicotinamide Riboside (NR)
Items of analysis
|Appearance||pale yellow to white powder||pale yellow powder|
|NR Purity by HPLC||NLT 98%||98.10%|
|NR Content by HPLC||NLT 20%||27.80%|
What is Nicotinamide Riboside?
Nicotinamide riboside, or NR, is a naturally-occurring version of vitamin B3 that works within our cells to support a number of cellular processes that support healthy aging, cellular energy, brain function, liver health, and metabolism.
Nicotinamide riboside (NR) was first described in 1944 as a growth factor, termed Factor V, for Haemophilus influenza, a bacterium that lives in and depends on blood. Factor V, purified from blood was shown to exist in three forms: NAD+, NMN and NR. NR was the compound that led to the most rapid growth of this bacterium.Notably, H. influenza cannot grow on nicotinic acid, nicotinamide, tryptophan or aspartic acid, which were the previously known precursors of NAD+.
In 2000, yeast Sir2 was shown to be an NAD+-dependent protein lysine deacetylase,which led several groups to probe yeast NAD+ metabolism for genes and enzymes that might regulate lifespan. Biosynthesis of NAD+ in yeast was thought to flow exclusively through NAMN (nicotinic acid mononucleotide).
When NAD+ synthase (glutamine-hydrolysing) was deleted from yeast cells, NR permitted yeast cells to grow. Thus, these Dartmouth College investigators proceeded to clone yeast and human nicotinamide riboside kinases and demonstrate the conversion of NR to NMN by nicotinamide riboside kinases in vitro and in vivo. They also demonstrated that NR is a natural product, a little-noticed vitamin found in cow's milk.
Health Benefits of Nicotinamide Riboside:
1) Nicotinamide Riboside Helps Muscle Function
NR administration rapidly restored muscle mass. Additionally, it preserved muscle NAD levels and exercise capacity in older mice, helping maintain muscle mass and function.
Mitochondrial myopathy is a disease where the mitochondria in muscle cells are damaged. It can cause muscle weakness and other problems.
Oral administration of NR in mice delayed myopathy progression by preventing mitochondrial abnormalities. NR supplementation reduced NAD+ consumption, which improved mitochondrial function.
NR also stimulated mitochondrial unfolded protein response, which protects against mitochondrial disease.
2) Nicotinamide Riboside Helps Fight Against Cancer
NR can be used to generally limit tumor growth in mice with high levels of oxidative stress.
Low levels of NAD+ synthesis can cause DNA damage. NR supplementation increases NAD+ levels, which can help protect against DNA damage, oxidative damage, and tumor progression .
3) Nicotinamide Riboside Reduces Diabetic Symptoms
In prediabetic mice, NR supplementation improved glucose tolerance, reduced weight gain, and reduced liver damage. In Type 2 diabetic mice, NR greatly reduced blood glucose and protected against diabetic nerve problems.
4) Nicotinamide Riboside Protects the Brain
Proper NAD metabolism can help protect the brain. NR protects the nerve cells in the brain by activating the SIRT3 (R) and PGC1a (R) pathways.
NR can also delay axonal degeneration, which can preserve nerve cells. Supplementation stimulates the NAD pathways and helps prevent degeneration in the brain.
NR improved cognitive function, and slowed progression of Alzheimer’s disease in mice given NR for 3 months.
5) Nicotinamide Riboside Protects the Liver
Oral administration of NR naturally increases NAD in the body, which helps protect the liver.
NR stopped fat accumulation, lowered oxidative stress, prevented inflammation, and improved insulin sensitivity in the liver of mice.
6) Nicotinamide Riboside Prevents Hearing Loss
Administration of NR, even after noise exposure, prevents noise-induced hearing loss in mice. It reduces degeneration of nerve cells caused by noise exposure.
SIRT3 mediates these effects.
7) Nicotinamide Riboside Increases Metabolism
In mice, supplementation of NR (400mg/kg) increased NAD+ levels in muscles, which increased their energy use and metabolism.
8) Nicotinamide Riboside May Help with Weight Loss
NR may increase enzymes involved in burning fat (sirtuin enzymes), and energy expenditure thus helping with weight loss.
9) Nicotinamide Riboside Increases Longevity
NR increases the amount of NAD in the body, which can help reprogram dysfunctional cells. These combined effects can help increase longevity in mammals.
NR induced the mitochondrial unfolded protein response and synthesis of prohibitin proteins, and this rejuvenated stem cells in aged mice.
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|Product name||CAS number|
|Beta nicotinamide mononucleotide||1094-61-7|
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