NSI-189 Nootropics Antidepressant Drug CAS 1270138-40-3 White Powder 99% Purity

NSI-189 Nootropics Antidepressant Drug CAS 1270138-40-3 White Powder 99% Purity

Chemical name: NSI-189
MF: C22H30N4O
MW: 366.4998
CAS: 1270138-40-3
Appearance: white powder
Purity: over 99%
Package: 200G/foil bag

Description:

NSI-189 is an experimental antidepressant. Neuralstem, Inc is currently testing it for use in major depression, in addition to treating cognitive impairments, and brain degeneration. It may induce specific brain regeneration.

NSI-189 is most likely selective only to two nervous system controlling regions in the brain (hippocampus, subventricular zone).

Benefits Of NSI-189:

1. May Improve Cognition

NSI-189 may improve cognition.

It can improve Long-Term Potentiation (LTP).

For example, in genetic altered mice to have Angelman Syndrome, NSI-189 taken orally could return LTP to these mice.

NSI-189 may also protect against radiation-induced memory impairment.

NSI-189 can also increase neurotrophic factors such as Stem Cell Factor (SCF), Brain-Derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and Glial-Derived Neurotrophic Factor (GDNF).

2. May Improve Depression

Destruction of the hippocampus is a common pathology in Major Depressive Disorder (MDD).

NSI-189 may effectively treat MDD as well as other psychiatric disorders by increasing neurogenesis (growth) in the hippocampus.

Although in 2017, it was announced that a phase II clinical trial with 220 patients failed to meet its primary effectiveness endpoint in MDD.

3. May Help With Stroke
NSI-189 may improve motor function and hippocampal deficits seen in oxygen-deficit (hypoxia) stroke.

One reason for this is by NSI-189's ability to significantly increase the neurotrophic factors VEGF, BDNF, GDNF, and SCF.

For example, in mice that were given a stroke, NSI-189 treatment continually helped improve deficits in these mice, even after cessation of the drug.

4. May Help With Diabetes
NSI-189 may be able to protect nerves from toxicity in diabetes.

It may help with nerve pain and neuropathy in diabetes.

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