Exemestane Anti Estrogen Steroids White Powder, Breast Cancer Treatment Drug CAS: 107868-30-4

Description:

Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive, hormonally-responsive, or hormone-receptor-positive. Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers.

Basic information:

Chemical name: Exemestane
Product Category: Pharmaceutical raw materials and intermediates
Product content: ≥ 99%
CAS Number: 107868-30-4
Molecular formula: C20H24O2
Molecular Weight:296.40
Packing specifications: 25kg / barrel
Molecular weight: 296.4
Appearance: White or Almost White Crystalline Powder
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Assay(by HPLC): 98.0-101.2%min
Usage: Developed to help fight breast cancer, Aromasin is one of the most powerful estrogen suppressing compounds.

Uses:

This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Exemestane decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.

Exemestane is usually not used in women of childbearing age.

How it works:

Some breast cancers are stimulated to grow by the hormone oestrogen. In women who have been through the menopause, oestrogen is no longer produced by the ovaries. But some oestrogen is still made in body fat using an enzyme (a type of protein) called aromatase. Aromatase inhibitors stop this enzyme from working so there’s less oestrogen in the body.

Exemestane will only be prescribed if your breast cancer has receptors within the cell that bind to the hormone oestrogen, known as oestrogen receptor positive or ER+ breast cancer. All breast cancers are tested for oestrogen receptors using tissue from a biopsy or after surgery. When oestrogen binds to these receptors, it can stimulate the cancer to grow.

When oestrogen receptors are not found (oestrogen receptor negative or ER- breast cancer) tests may be done for progesterone (another hormone) receptors. The benefits of hormone therapy are less clear for people whose breast cancer is only progesterone receptor positive (PR+ and ER-). Very few breast cancers fall into this category. However, if this is the case for you your specialist will discuss with you whether exemestane is appropriate.

If your cancer is hormone receptor negative, then exemestane will not be of any benefit.

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