Place of Origin: | China |
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Brand Name: | YW |
Certification: | GMP, ISO9001, USP, KOSHER |
Model Number: | 96829-58-2 |
Minimum Order Quantity: | 10 grams |
Price: | Negotiable |
Packaging Details: | Discreet disguised package or as required |
Delivery Time: | 3~7 working days |
Payment Terms: | Western Union, Moneygram, Bitcoin and Bank Wire Transfer |
Supply Ability: | 5000kg/week |
Appearance: | White Powder | Assay: | Over 99% |
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Usage: | Treating Obesity | CAS Number: | 96829-58-2 |
MF: | C29H53NO5 | MW: | 495.73 |
Email: | Sinosource6666@gmail.com | Whatsapp: | +86-13657291547 |
High Light: | weight loss steroids,fat loss steroids |
White Anti Obesity Raw Powder CAS: 96829-58-2 Orlistat Fermentative Form
Description:
Orlistat ( also known as tetrahydrolipstatin ) is a drug designed to treat obesity . Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor , thereby reducing caloric intake . It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet .
Orlistat is the saturated derivative of lipstatin , a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini . However , due to its relative simplicity and stability , orlistat was chosen over lipstatin for development as an anti-obesity drug .
The drug does not need to be absorbed through the body. At normal doses, the absorption of fat can be inhibited by 30%. There is little absorption after oral administration. It can be subject to metabolic inactivation in the intestine with the metabolic sites located in the gastrointestinal wall. The elimination half-life is about 14 to 19 hours. About 97% of the goods are excreted with the feces, of which 83% are in the prototype.
Clinically orlistat can be applied to the treatment of obesity and hyperlipidemia. Under normal circumstances, it can be subject to oral administration at a dose of 120 mg for three times per day. Take it during the meal or 1 hour after a meal. After 2 weeks of administration, the body weight can begin to decline. It can be taken continuously for 6 to 12 months. If the dose is increased to above 400 mg daily, the effect will no longer be further enhanced.
Basic information:
Chemical Names: Orlistat; 96829-58-2; Tetrahydrolipstatin; Xenical; Alli; Orlipastat More...
Molecular Formula: C29H53NO5
Molecular Weight: 495.745 g/mol
CAS: 96829-58-2
Appearance: white powder
Usage: Treating obesity
Purity: 99%
COA
Items |
Specification Items |
Appearance | white or almost white crystalline powder,smell less |
Melting Point | 42.0~46.0°C |
Specific Rotation | -31°~-39°(CHCl3,C=1) |
Identification | The result of HPLC is consisitent to the reference one. The result of IR is consisitent to the reference one. |
Related Substances | ≤ 0.5% |
Total impurity | ≤ 1.0% |
Single impurity | ≤ 0.1% |
n-Hexane | ≤ 290ppm |
Isopropyl ether | ≤ 5000ppm |
Residual on Ignition | ≤0.1% |
Sulphate | ≤ 0.05% |
Heavy Metal | ≤ 20ppm |
Purity | ≤ 99.0% ~ 99.9% |
Background:
Orlistat (or' li stat) is a tetrahydrolipstatin, a saturated derivative of lipstatin which is a potent natural inhibitor of gastric and pancreatic lipase. Orlistat when taken with meals inhibits the digestion of dietary fats and prevents their absorption, thus reducing caloric intake. When used in conjunction with caloric restriction and exercise, orlistat improves weight loss. Orlistat was approved for use in the United States in 1999, and an over-the-counter formulation of the drug was approved in 2007. Orlistat is available by prescription as capsules of 120 mg in generic forms and under the trade name Xenical and over-the-counter as capsules of 60 mg under the trade name Alli. The usual dose is one capsule three times daily before meals. Orlistat is minimally, if at all, absorbed, and its side effects are largely due to its effect on fat absorption including abdominal discomfort, bloating, gaseousness, diarrhea, fecal leakage and steatorrhea (oily stools and fat-soluble vitamin malabsorption). Symptoms are particularly prominent if orlistat is given before a high fat meal and they tend to lessen with more prolonged therapy (perhaps due to its adverse effects, leading to a lower fat diet).
How to get the most from your Orlistat treatment.
Eat well - but try to cut down your dietary calories by about 500 calories per day. This should result in the loss of 1lb per week, a healthy weight loss
Eat slowly and enjoy your food - don’t rush (this will keep any hunger at bay)
Exercise regularly
Avoid temptation - keep the cupboards free from unhealthy foods
Know that weight loss takes time. Have realistic goals in mind, monitor your progress and don’t give up!
Applications:
1. | Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. In the intestine, an enzyme called lipase (produced primarily by the pancreas) breaks apart fat in food so that it can be absorbed into the body. |
2. | Orlistat blocks the action of lipase and thereby prevents the breakup and absorption of fat. Orlistat blocks absorption of about 25% of the fat in a meal. The unabsorbed fat is excreted in the stool. |
3. | Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug. |
4. | Dietary fats need to be broken down into smaller pieces before the body can absorb them. Orlistat works by blocking the enzyme that breaks down fats in your diet. This undigested fat then passes out of your body in your bowel movement. |
5. | Orlistat does not block the absorption of calories from sugar and other non-fat foods, so you still need to restrict your total intake of calories. |
6. | Orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). In the United States and the European Union, orlistat is available for sale without a prescription. Generic formulations of orlistat are available in some countries |
How should this medicine be used?
Orlistat comes as a capsule and a nonprescription capsule to take by mouth. It is usually taken three times a day with each main meal that contains fat. Take orlistat during a meal or up to 1 hour after a meal. If a meal is missed or does not have fat, you may skip your dose. Follow the directions on your prescription label or the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take orlistat exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or stated on the package.
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