Local Anaesthetic Lidocaine Hydrochloride CAS: 6108-05-0 as Pain Killer White Powder
Lidocaine Hydrochloride is the hydrochloride salt from of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.
Chemical Name:Lidocaine hydrochloride
Synonymsdolicaine;LINOCAINE HCL;Lidocaine HCl USP;Linocaine hydrochlor;LIDOCAINE HCL HYDRATE;-N-(2,6-dimethylphenyl);LINOCAINE HYDROCHLORIDE;LidocaineHclLidocaineHclBp;Linocaine hydrochloride hydrate;Lidocaine Hydrochloride hydrate
Molecular Formula: C14H25ClN2O2
Formula Weight: 288.81
Melting point: 75-79℃
solubility H2O: soluble
Water Solubility:Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.
|Product name||Lidocaine hydrochloride|
|CAS No.||73-78-9||Outer Packing||25KG/Drum|
|Production date||2016-10-22||Shelf life||2021-10-21|
|Items of analysis||Specification||Results|
|Appearance||White crystalline powder||White crystalline powder|
|residue on ignition||≤0.1%||0.05%|
|residual solvent||methyl alcohol≤0.5% Methanol ≤0.5% Methylbenzene ≤0.089% Toluene ≤0.089||0.068% 0.002%|
|Related substance||Impurity A≤0.01% Unknown single impurity≤0.1%||Not detected 0.01%|
Local numbing agent
The efficacy profile of lidocaine as a local anaesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anaesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for spinal and epidural anaesthesias; lidocaine, though, has the advantage of a rapid onset of action. Adrenaline vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia.
Lidocaine is one of the most commonly used local anaesthetics in dentistry. It can be administered in multiple ways, most often as a nerve block or infiltration- depending on the type of treatment carried out and the area of the mouth worked on.
For surface anaesthesia, several formulations can be used for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local numbing less painful.Lidocaine drops can be used on the eyes for short ophthalmic procedures. There is tentative evidence for topical lidocaine for neuropathic pain and skin graft donor site pain.As a local numbing agent, it is used for the treatment of premature ejaculation.
Lidocaine is also the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine preventative dose is no longer recommended after a myocardial infarction as the overall benefit is not convincing.
|Product name||CAS NO.||Product name||CAS NO.|
|Procaine HCl||51-05-8||Lidocaine HCl||73-78-9|
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