CAS 96 48 0 Sex Enhancing Drugs Pharmaceutical Materials GBL Gamma Butyrolactone Colorless Liquid

CAS 96-48-0 Pharmaceutical Materials / GBL Gamma Butyrolactone Colorless Liquid

Description:

γ-Butyrolactone (GBL) is a hygroscopic colorless liquid with a weak characteristic odor. Soluble in water, GBL is a common solvent and reagent in chemistry as well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for γ-hydroxybutyric acid (GHB), and it is used as a recreational intoxicant with effects similar to alcohol.

A milliliter of pure GBL metabolizes to the equivalent 1.65g of NaGHB, the common form, so doses are measured in the single milliliter range, either taken all at once or sipped over the course of a night.

GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.

GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood. Animals which lack these enzymes exhibit no effect from GBL. GBL is more lipophilic (fat soluble) than GHB, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent and faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.

Quick details:

Produce Name:Gamma-Butyrolactone

Synonyms: Gamma Butyrolactone, 1, 4- Butyrolactone, γ -Butyroladone, GBL, BLO,

CAS number: 96-48-0

EINECS number: 202-509-5

Formula: C4H6O2

M. W.: 86.09

Assay: 99.8%

Appearance: Colorless oily liquid
Packaging: 200KG/Galvanized iron drum.

COA

Applications

Frequent use of GHB / GBL, even when taken long-term and in moderate doses, does not appear to cause significant physical dependency in the majority of its users. In many people, quitting or temporarily abstaining from use of the drugs is achieved with minimal or no difficulty. However, when consumed in excessive amounts with a high frequency of dosing, physical and psychological dependence can develop. Management of GBL dependence involves considering the person's age, comorbidity and the pharmacological pathways of GBL.

There are some reports of GHB/GBL users adopting a '24/7' dosing regime. This is where the user has become tolerant to the effects of the drug, increasing the dosage and frequency of dosage simply to avoid withdrawal symptoms.

For those users who do report withdrawal symptoms upon quitting the use of GHB / GBL, symptoms seem to depend on the dosage and the length of time the drug was used. Light to moderate users often experience insomnia and sleep - related problems, whereas heavy, prolonged use can cause severe withdrawal symptoms similar to Benzodiazepine withdrawal syndrome.

Gamma-Butyrolactone Storage and transportation:

1. Storage: All products should be stored at a dry and ventilated location away from fire and other dangerous goods, and should avoid direct sunlight.

2. Transportation: During the transportation process, all containers should be free of leak, collapse,falling and damage. It should be handled lightly to prevent damage to the package. It is prohibited to be transported together with toxic and corrosive materials. In the transport process, all product should be prevented from the sun and rain and should keep away from fire, heat and high-temperature zone.

Shelf life: All products have a shelf life of one year under the specified storage conditions.

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