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White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

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White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2
White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

Large Image :  White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2 Get Best Price

Product Details:
Place of Origin: CN
Brand Name: YW
Certification: ISO9001,BRC,KOSHER
Model Number: 62-44-2
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiation
Packaging Details: Discreet package
Delivery Time: 5-8 working days
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 5-8 working days
Detailed Product Description
Product Name: Phenacetin CAS: 62-44-2
MF: C10H13NO2 MW: 179.22
EINECS: 200-533-0 Appearance: White Crystalline Powder
High Light:

local anesthetic powder

,

pain relief powder

 
CAS:62-44-2 White Flash Scaly Crystalline Powder Pharmaceutical Grade Phenacetin Anti Inflammatory Pain Relieving Drugs
 
 
Basic information
 
 
Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. It was introduced into therapy in 1887 and was extensively used in analgesic mixtures until it was implicated in kidney disease (nephropathy) due to abuse of analgesics. Phenacetin also was once used as a stabilizer for hydrogen peroxide in hair-bleaching preparations
Product Name: Phenacetin
Synonyms: 1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4'-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE
CAS: 62-44-2
MF: C10H13NO2
MW: 179.22
EINECS: 200-533-0
Product Categories: Other APIs;Organics;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 62-44-2.mol
Phenacetin Structure
Phenacetin Chemical Properties
Melting point 133-136 °C(lit.)
Boiling point 132 °C / 4mmHg
Fp 2℃
storage temp. 2-8°C
form powder
color White
Water Solubility 0.076 g/100 mL
Sensitive Hygroscopic
Merck 14,7204
BRN 1869238
Stability: Stable. Incompatible with strong oxidizing agents, strong acids.
 
 
Uses:
 
 
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C.," or "aspirin-phenacetin-caffeine" compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia.
 
But the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November of 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.As a result, some branded, and previously phenacetin-based, preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.
 
Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.
Due to its low cost, phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.
 
 
Product Description:
 
Phenacetin (or acetophenetidin) is a pain-relieving and fever-reducing drug, which was widely used between its introduction in 1887 and the 1983 ban imposed by the FDA on its use in the United States. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized as paracetamol (acetaminophen), which replaced it in some over-the-counter medications following the ban on phenacetin.
 
It is also called acetophenetidins. Having glossy leaflets or scales-like crystals that have no odor or taste.Melting point 134 ~ 137. Stable in air, soluble in water, slightly soluble in boiling water, slightly soluble in ether, soluble in ethanol, chloroform. It is formed through the etherification,reduction and Acetylation reaction of p-chloronitrobenzene. As chloroacetanilide antipyretic and analgesic agent. Suitable for fever,headache, neuralgia and other drugs as a compound agent.
 
 
 
COA:
 
Item Specifications Results
Description White or almost white crystalline powder Conform
Identity 1,IR complies Conform
  2,X-Ray complies Conform
  3,HPLC complies Conform
Optical rotation -77.0 -78.0
Loss on drying Not more than 0.5% 0.32%
Related substances 1,Cabergolin Imp A no more than0.15% 0.05%
  2,Allylamide no more than 0.10% 0.03%
  3,Allyl DHLA no more than 0.15% 0.06%
  4,Cabergoline oxide no more than 0.10% 0.04%
  5,Other impurities individually no more than 0.10% 0.03%
  6,Total no more than 0.50% 0.21%
Assay(HPLC) 98.0%~102.0%(recalculated on anhydrous basis) 99.4%
Residual solvents 1,Dichloromethane no more than 100ppm 15ppm
  2,Acetone no more than 200ppm 15ppm
  3,Tert-butylmethylether no more than 200ppm 11ppm
  4,Xylene no more than 1500ppm 135ppm
  5,Heptane no more than 1000ppm 20ppm
Residue on ignition No more than0.10% 0.03%
Heavy metals No more than 20ppm 1ppm
Particle size 90% of particles no more than 80um Conform
Bulk density 0.20~0.35g/cm3 0.33g/cm3
Conclusion The results conforms with EP6.0/USP30 standard.
 
 
Mechanism of action:
 
 
Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.
 
 
It is metabolized in the body to paracetamol (acetaminophen), which is also a clinically relevant analgesic.
 
 
Phenacetin Function
 
 
Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin,low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic effect. Because the enzyme inhibitor make Phenacet-Acetate not be converted into paracetamol, still showed obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The mild Phenacet-Acetate analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet.
 
 

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We have professional team for package and shipment.Unique ways to ship 10g to 100kg powders at one time to your country.Our shipments are by EMS,DHL,TNT,FEDEX,HKEMS,UPS,etc for 25kg,between 25kg-200kg by air,over 200kg by sea.Fast and secure shipment could be arranged for customs pass guaranteed.

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