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|Purity:||≥98%||Usage:||Local Anesthetic Drug|
pain relief powder,
local anesthetic drugs
Trimethoprim White Powder for Treating Urinary infection CAS 738-70-5
Chemical name: Trimethoprim
Appearance: white powder
Purity: over 99%
Items of analysis
|Characters||A white or yellowish-white powder||Up to standard|
|Solubility||Very slightly soluble in water, slightly soluble in alcohol, practically insoluble in ether||Very slightly soluble in water, slightly soluble in alcohol|
|specific absorbance||maximum at 287nm. 240 to 250||243|
Action: How Alprim works:
Alprim belongs to a group of medicines called antibiotics. It works by stopping the growth of the bacteria that is causing your infection.
Alprim will not work against infections caused by viruses, such as colds or flu.
The active ingredient in Alprim is trimethoprim. Each Alprim tablet contains 300 mg of trimethoprim.
The tablets also contain the following inactive ingredients lactose, povidone, sodium starch glycollate, purified talc, magnesium stearate.
It is primarily used in the treatment of urinary tract infections, although it may be used against any susceptible aerobic bacterial species.It may also be used to treat and prevent Pneumocystis jirovecii pneumonia.It is generally not recommended for the treatment of anaerobic infections such as Clostridium difficile colitis (the leading cause of antibiotic-induced diarrhea).Trimethoprim has been used in trials to treat retinitis.
Resistance to trimethoprim is increasing, but it is still a first line antibiotic in many countries.
Mechanism of action:
Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF).THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.Trimethoprim's affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase.Sulfamethoxazole inhibits dihydropteroate synthase, an enzyme involved further upstream in the same pathway.Trimethoprim and sulfamethoxazole are commonly used in combination due to possible synergistic effects, and reduced development of resistance.This benefit has been questioned.
Trimethoprim alone is probably most commonly used for urinary tract infections (cystitis). It can be used both to treat a urinary tract infection and also sometimes to help prevent them (e.g. in people who keep getting this type of infection). Trimethoprim may also be used for some other bacterial infections; in this case it is often combined with another antibiotic as co-trimoxazole. There are some bacteria that are not affected by trimethoprim (resistant).
Trimethoprim works by stopping a step in the process of making DNA in bacteria.
To clear up a urinary tract infection the usual adult dose is 300 mg once a day. Children take between 40 mg and 150 mg once daily depending on age. Usually trimethoprim is taken for a three to five day course. Higher doses as a single dose are also effective in treating uncomplicated urine infections.
To prevent a urinary tract infection the usual adult dose is 100 mg once a day for adults and children over 12 years. Children take between 25 mg and 50 mg once a day.
The tablets are usually taken at bedtime, and can be taken with food to help to prevent stomach upset.
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