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Pharmaceutical Raw Materials Gabapentin Hydrochloride Anticonvulsant and Analgesic Drug CAS 60142-96-3
(1) Gabapentin (Neurontin) is an anticonvulsant and analgesic drug. It was originally developed to treat epilepsy, and is currently also used to relieve neuropathic pain. It is recommended as a first line agent for the treatment of neuropathic pain arising from diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain.
(2)Gabapentin is also commonly prescribed for many off-label uses, such as treatment of restless leg syndrome, anxiety disorders, insomnia, and bipolar disorder. There are, however, concerns regarding the quality of the trials conducted and evidence for some such uses, especially in the case of its use as a mood stabilizer in bipolar disorder.
(3)Two related drugs, pregabalin and a prodrug form called gabapentin enacarbil, are available.
(1) The mechanism of the anticonvulsant action of gabapentin has not been fully described. Though similar in structure to the endogenous neurotransmitter GABA, gabapentin has not been shown to bind to GABA receptors at concentrations at or below 1000 µ M. Gabapentin modulates the action of glutamate decarboxylase (GAD) and branched chain aminotransferase (BCAT), two enzymes involved in GABA biosynthesis. In human and rat studies, gabapentin was found to increase GABA biosynthesis, and to increase non-synaptic GABA neurotransmission in vitro.
(2) Gabapentin (0.01-100 µ M) has not been shown to interact with the sodium or L-type calcium ion channels targeted by the conventional anticonvulsant drugs phenytoin, carbamazepine and sodium valproate. Other neurophysiological findings indicate that gabapentin does not interact with glutamate, glycine, or NMDA receptors, further distinguishing its anticonvulsant mechanism from that of common antiepileptic medications.
Product Name: Gabapentin Hydrochloride
Appearance: White powder
Certification: ISO 9001, USP, BP
Packing: Discreet packing ways as your requirement,100% go through
Storage: Store in cool and dry area and keep away from direct sunlight
Usage: Amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.
Gabapentin is FDA approved to treat seizures and neuropathic pain.It is primarily administered by mouth, with a study showing that "rectal administration is not satisfactory". It is also commonly prescribed for many off-label uses, such as treatment of anxiety disorders, insomnia, and bipolar disorder.About 90% of usage is for off-label conditions.There are, however, concerns regarding the quality of the trials conducted and evidence for some such uses, especially in the case of its use as a mood stabilizer in bipolar disorder.
Gabapentin may be useful in the treatment of comorbid anxiety in bipolar patients; however, it is not effective as a mood-stabilizing treatment for manic or depressive episodes themselves. Other psychiatric conditions, such as borderline personality disorder, have also been treated off-label with gabapentin. There is insufficient evidence to support its use in obsessive–compulsive disorder and treatment-resistant depression.
Gabapentin may be effective in acquired pendular nystagmus and infantile nystagmus (but not periodic alternating nystagmus). It is effective for treating hot flashes. It may be effective in reducing pain and spasticity in multiple sclerosis.
Gabapentin may reduce symptoms of alcohol withdrawal (but it does not prevent the associated seizures), alcohol dependence and craving. There is some evidence for its role in the treatment of alcohol use disorder; the 2015 VA/DoD guideline on substance use disorders lists gabapentin as a "weak for" and is recommended as a second-line agent.Use for smoking cessation has had mixed results. There is insufficient evidence for its use in cannabis dependence.
Gabapentin is effective in alleviating itching in kidney failure (uremic pruritus) and itching of other causes. It is an established treatment of restless legs syndrome.Gabapentin may help sleeping problems in people with restless legs syndrome and partial seizures due to its increase in slow-wave sleep and augmentation of sleep efficiency.Gabapentin may be an option in essential or orthostatic tremor.Gabapentin does not appear effective for the treatment of tinnitus.
The most common side effects of gabapentin include dizziness, fatigue, drowsiness, ataxia, peripheral edema (swelling of extremities), nystagmus, and tremor.Gabapentin may also produce sexual dysfunction in some patients, symptoms of which may include loss of libido, inability to reach orgasm, and erectile dysfunction. Gabapentin should be used carefully in people with kidney problems due to possible accumulation and toxicity.
Some have suggested avoiding gabapentin in people with a history of myoclonus or myasthenia gravis, as it may induce or mimic the symptoms of these two conditions.
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