Pentadecapeptide Bpc 157 Human Growths Hormones Supplements Peptide CAS 137525-51-0
Alias : Booly Protection Compound 15, Pentadecapeptide, BPC 157
CAS : 137525-51-0
Sequence : Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
MF : C62H98N16O22
MW : 1419.53552
Purity : 99%
Specification : 2mg/vial
Appearance : White Lyophilized Powder
Standard : USP
Certification : SGS
Method of Analysis : HPLC
Storage : Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.
||Lyophilized White Powder
||Bpc 15, Bpc-157, Booly protection compound 15
||BPC 157 is stable at room temperature for 90 days, It should be stored in a freezer for any extended period of time.
||»Certificate of Analysis »HPLC Report »Mass Spectrum
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1. BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease.
2. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.
3. FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.
Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a very safe profile, and exhibited a particular wound healing effect.
It also has shown to interact with the NO-saystem, providing endothelium protection and angiogenic effect, even in severely impaired conditions (i.e., it stimulated expression of early growth response 1 gene responsible for cytokine and factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve factor 1- A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD.
Hopefully, the lessons from animal studies, particularly advanced intestinal anastomosis healing, reversed short bowel syndrome and fistula healing indicate BPC 157s high significance in further IBD therapy. Also, this supportive evidence (i.e., no toxic effect, limit test negative, LD1 not achieved, no side effect in trials) may counteract the problems commonly exercised in the use of peptidergic agents, particularly those used on a long-term basis.
(1) BPC 157 has been shown in rat studies to heal torn quadriceps muscles, detached achilles tendon, muscles that have been damaged/crushed
(2) Dramatic fast recovery from muscle tears
(3) Tendon to bone healing
(4) Increased ligament healing
(5) Has a variety of protective effects in the organs
(6) Human trials demonstrate healing and prevention of stomach ulcers
(7) No adverse reactions have been seen in human trials.
How Much BPC-157 To Take
There is an abundance of research on BPC-157 and it has been shown to be effective systematically when injected once daily at anywhere from 1-10mcg per kg of body weight. In most cases, this comes out to a dose of anywhere from 200mcg up to 800mcg. Some folks report the most success dosing twice per day with 250-350mcg for a total of 500-700mcg per day. So as you can see, there’s quite a bit of variability in dosage recommendations. I initially began to use BPC-157 for golfer’s elbow (inner elbow pain also known as “climber’s elbow” or “medial epicondylitis), and I personally, based on the majority of the research studies in humans, settled upon a self-administered subcutaneous BPC-157 injection of 250mcg in my left elbow on one day, then 250mcg in my right elbow the next day, for a total of two weeks. At this point, my elbow pain had completely disappeared, so I stopped.
Although, as I’ve mentioned, BPC-157 is free of side effects at normal dosages, I can tell you that the first time I used it, I accidentally dosed with 2500mcg instead of the 250mcg I planned to initially trial with, and I felt for about the next four hours what I would best describe as a slight amount of irritability and grumpiness, which was likely due to the anabolic cortisol response from a very minor overdose. This feeling passed within four hours, and I’ve felt no ill-effects since with daily dosing of 250mcg.
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