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|Appearance:||White Powder||Assay:||Over 99%|
|Package:||25KG/fiber Drum||CAS Number:||51-05-8|
local anesthetic powder,
local anesthetic drugs
Local anesthetic Drug Procaine hydrochloride CAS: 51-05-8 Raw Powder
Procaine hydrochloride is a salt of the compound Procaine. Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, Procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), Procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line (HEK293), the presence of procaine is reported to potently inhibit nicotinic acetylcholine receptors. Procaine is available alone (sc-296134) and in its salt form as Procaine HCl.
Chemical name: Procaine hydrochloride
Appearance: White powder
Package: 25KG/fiber drum
Stability: ≥ 2 years
|Product name||Procaine Hydrochloride|
|CAS No.||51-05-8||Outer Packing||25KG/drum|
|Production date||2017.08.25||Shelf life||2020.08.24|
|Items of analysis||Specification||Results|
|Description||A white crystalline powder or colourless crystals||Complies|
|Identification||IR Absorption/Reaction of chlorides /Reaction of primary aromatic amines||Complies|
|Color and clarity of solution||Colorless and clear||Conforms|
|pH (Acidity)||5.0~6.5 (≤0.02NNaOH0.5ml)||5.5/0.2ml|
|Loss on drying||≤0.5%||0.16%|
|Assay(C 13 H 20 N 2 O 2 .HCl)||99.0~101.0%||99.8%|
Local anesthesic;Na+ channel blocker
Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.
Non Caine local anesthetic.
A sodium channel blocker and DNA methylation inhibitor
For solution and drug compatibility information, see Compatibility under Stability.
Administer by local infiltration, peripheral nerve block, or subarachnoid (spinal) block.a c d Has been administered by continuous intra-articular infusion† (e.g., for control of postoperative pain); however, such use associated with chondrolysis.200 201 202 203 204 205 206 207 208 209 (See Risk of Chondrolysis Associated with Intra-articular Infusions of Local Anesthetics under Cautions.)
Consult specialized references for specific techniques and procedures for administering local anesthetics.
For local infiltration or peripheral nerve block, inject slowly and avoid rapid injection of large volumes; when feasible, administer in fractional (incremental) doses.
For subarachnoid (spinal) block, use 2-mL single-dose ampuls containing procaine hydrochloride 10% only.c d Position patient properly prior to spinal anesthesia.
For disinfection of container surface, autoclave once at 15 PSI and 121°C for 15 minutesa (diluent dextrose may show some brown discoloration due to caramelization); immersion in antiseptic solution not recommended.c Reautoclaving not recommended because it increases likelihood of crystal formation.
For local infiltration, dilute appropriate dose of 1% procaine hydrochloride injection with 0.9% sodium chloride to obtain final concentration of 0.25 or 0.5%.a d May add 0.5-1 mL of epinephrine 0.1% to each 100 mL of anesthetic solution (to provide final epinephrine concentration of 1:200,000 to 1:100,000) for vasoconstrictive effect.
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