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|Appearance:||White Powder||Assay:||Over 99%|
|Usage:||Local Anesthesia||CAS Number:||103-90-2|
local anesthetic powder,
local anesthetic drugs
Fever Reducing Medicine Paracetamol CAS: 103-90-2 for Reliving the Pain
Paracetamol is a commonly used medicine that can help treat pain and reduce a high temperature (fever).
It's typically used to relieve mild or moderate pain, such as headaches, toothache or sprains, and reduce fevers caused by illnesses such as colds and flu.
Paracetamol is often recommended as one of the first treatments for pain, as it's safe for most people to take and side effects are rare.
English name: 4-Acetamidophenol
Synonyms: Acetaminophen; 4-Hydroxyacetanilide; Paracetamol; APAP; p-Hydroxyacetanilide; 4-Acetamino phenol; Acetaminphen; Paracetamol DC; N-Acetyl-4-aminophenol; N- (4-hydroxyphenyl) acetamide; Acetamiophen
EINECS Number: 203-157-5
Water-soluble: 14 g / L (20 ºC)
Melting point 168-172 ° C
Water-soluble 14 g / L (20 ° C)
Appearance: White crystalline powder
How to take paracetamol:
Make sure you take paracetamol as directed on the label or leaflet, or as instructed by a health professional.
How much you can take depends on your age, your weight, the type of paracetamol you're taking and how strong it is. For example:
Adults can usually take one or two 500mg tablets every 4-6 hours, but shouldn't take more than 4g (eight 500mg tablets) in the space of 24 hours.
Children under 16 need to take a lower dose, depending on their age or weight - check the packet or leaflet, or ask a pharmacist or doctor for advice. For very young children, paracetamol liquid is given using a measuring spoon or an oral syringe.
Paracetamol should start to work within an hour and the effect usually lasts several hours. Don't take more than the recommended dose if it isn't relieving your symptoms.
Adults can take ibuprofen at the same time if necessary, but this isn't usually recommended for children.
1. Medical uses:
Paracetamol is used for reducing fever in people of all ages. The World Health Organization (WHO) recommends that paracetamol be used to treat fever in children only if their temperature is greater than 38.5 °C (101.3 °F). The efficacy of paracetamol by itself in children with fevers has been questioned and a meta-analysis showed that it is less effective than ibuprofen.
Paracetamol is used for the relief of mild to moderate pain. The use of the intravenous form for pain of sudden onset in people in the emergency department is supported by limited evidence.
The American College of Rheumatology recommends paracetamol as one of several treatment options for people with arthritis pain of the hip, hand, or knee that does not improve with exercise and weight loss.A 2015 review, however, found it provided only a small benefit in osteoarthritis.
Paracetamol has relatively little anti-inflammatory activity, unlike other common analgesics such as the NSAIDs aspirin and ibuprofen, but ibuprofen and paracetamol have similar effects in the treatment of headache. Paracetamol can relieve pain in mild arthritis, but has no effect on the underlying inflammation, redness, and swelling of the joint.It has analgesic properties comparable to those of aspirin, while its anti-inflammatory effects are weaker. It is better tolerated than aspirin due to concerns about bleeding with aspirin.
Low back pain
Based on a systematic review, paracetamol is recommended by the American College of Physicians and the American Pain Society as a first-line treatment for low back pain.However, other systematic reviews concluded that evidence for its efficacy is lacking.
A joint statement of the German, Austrian, and Swiss headache societies and the German Society of Neurology recommends the use of paracetamol in combination with caffeine as one of several first line therapies for treatment of tension or migraine headache.In the treatment of acute migraine, it is superior to placebo, with 39% of people experiencing pain relief at 1 hour compared to 20% in the control group.
Paracetamol combined with NSAIDs may be more effective for treating postoperative pain than either paracetamol alone or NSAIDs alone.
The efficacy of paracetamol when used in combination with weak opioids (such as codeine) improved for approximately 50% of people but with increases in the number experiencing side effects.Combination drugs of paracetamol and strong opioids like morphine improve analgesic effect.
The combination of paracetamol with caffeine is superior to paracetamol alone for the treatment of common pain conditions including dental pain, postpartum pain, and headache.
2. Veterinary use:
Paracetamol is extremely toxic to cats, which lack the necessary glucuronyl transferase enzymes to break it down safely. Initial symptoms include vomiting, salivation, and discoloration of the tongue and gums.
Unlike an overdose in humans, liver damage is rarely the cause of death; instead, methemoglobin formation and the production of Heinz bodies in red blood cells inhibit oxygen transport by the blood, causing asphyxiation (methemoglobemia and hemolytic anemia).
Treatment with N-acetylcysteine,methylene blue or both is sometimes effective after the ingestion of small doses of paracetamol.
Although paracetamol is believed to have no significant anti-inflammatory activity, it has been reported as effective as aspirin in the treatment of musculoskeletal pain in dogs.
A paracetamol-codeine product (trade name Pardale-V) licensed for use in dogs is available on veterinary prescription in the UK.It should be administered to dogs only on veterinary advice and with extreme caution.
The main effect of toxicity in dogs is liver damage, and GI ulceration has been reported. N-acetylcysteine treatment is efficacious in dogs when administered within 2 hours of paracetamol ingestion.
Paracetamol is also lethal to snakes, and has been suggested as a chemical control program for the invasive brown tree snake (Boiga irregularis) in Guam.Doses of 80 mg are inserted into dead mice scattered by helicopter.
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