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|Appearance:||White Powder||Assay:||Over 99%|
|Usage:||Anti-inflammatory Agent||CAS Number:||25122-46-7|
local anesthetic powder,
local anesthetic drugs
Anti-inflammatory Drug Clobetasol Propionate CAS: 25122-46-7 White Powder
Clobetasol propionate is classed as a very potent topical corticosteroid. Topical corticosteroids are also referred to as topical steroids. Topical steroids are used in addition to moisturisers (emollients) for treating inflammatory skin conditions such as eczema and dermatitis. A topical steroid is used when patches of eczema or dermatitis flare up. Clobetasol propionate relieves the symptoms of a flare-up by reducing inflammation, itching and redness. It is not a cure for the condition, but it will help to relieve the symptoms.
Chemical name: Clobetasol propionate
Appearance: white powder
Usage: anti-inflammatory agent
|Product name||Clobetasol propionate|
|CAS No.||25122-46-7||Outer Packing||1KG/bag|
|Production date||Sep.,08, 2016||Shelf life||Sep.,07, 2019|
|Items of analysis||Specification||Results|
|Description||White or almost white crystalline powder||Almost white crystalline powder|
|Solubility||Practically insoluble in water,slightly soluble in benzene and diethyl ether ,sparingly soluble ethanol||Complies|
|Identification (IR)||Complies with the Standard||Complies|
|Melting point||about 196℃||195.0℃～197.0℃|
|Loss on drying||max.2.0%||0.20%|
|Residue on ignition||max. 0.1%||0.04%|
|Single impurity||N.m.t 1.0%||0.16%|
|Sum impurity||N.m.t 2.5%||0.46%|
|Organic volatile impurities||meet the ICH requirement||Complies|
|THF||Not more than 720ppm||Complies|
|Methanol||Not more than 3000ppm||Complies|
|DMF||Not more than 880ppm||Complies|
|Pyridine||Not more than 200ppm||Complies|
|Dichloromethane||Not more than 600ppm||Complies|
|Ethanol||Not more than 5000ppm||Complies|
|Acetone||Not more than 5000ppm||Complies|
Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis,psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases including alopecia areata, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.
Clobetasol proprionate is used cosmetically by dark-skinned women for skin whitening, although this use is controversial. The U.S. Food and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the U.S. Nonetheless, it is often sold in U.S. retail beauty supply stores and on the internet. It is also sold internationally, and does not require a prescription in some countries. Whitening creams with clobetasol proprionate, such as Hyprogel, can make skin thin and easily bruised, with visible capillaries, and acne. It can also lead to hypertension, elevated blood sugar, suppression of the body’s natural steroids, and stretch marks, which may be permanent.
Clobetasol propionate is, along with mercury and hydroquinone, "amongst the most toxic and most used agents in lightening products." Many products sold illegally have higher concentrations of clobetasol propionate than is permitted for prescription drugs.
How it works:
Clobetasol belongs to a class of drugs called topical corticosteroids. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Clobetasol works by decreasing your body's response to inflammation. It also reduces the activity of your immune system. This prevents inflammation and itching and treats your skin condition.
INDICATIONS AND USAGE:
Clobetasol propionate cream is a super-high potency corticosteroid formulation indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Use in pediatric patients under 12 years of age is not recommended. As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of the diagnosis may be necessary.
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