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CAS 1094-61-7 Legal Anabolic Steroids β- Nicotinamide Mononucleotide / β- NMN Raw Powder

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CAS 1094-61-7 Legal Anabolic Steroids β- Nicotinamide Mononucleotide / β- NMN Raw Powder

CAS 1094-61-7 Legal Anabolic Steroids β- Nicotinamide Mononucleotide / β- NMN  Raw Powder
CAS 1094-61-7 Legal Anabolic Steroids β- Nicotinamide Mononucleotide / β- NMN  Raw Powder CAS 1094-61-7 Legal Anabolic Steroids β- Nicotinamide Mononucleotide / β- NMN  Raw Powder

Large Image :  CAS 1094-61-7 Legal Anabolic Steroids β- Nicotinamide Mononucleotide / β- NMN Raw Powder Get Best Price

Product Details:
Place of Origin: China
Brand Name: YW
Certification: GMP, ISO9001, USP, KOSHER
Model Number: 1094-61-7
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: Discreet disguised package or as required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, Bank transfer
Supply Ability: 5000kg/week
Detailed Product Description
CAS No.: 1094-61-7 MF: C11H15N2O8P
MW: 334.22 Appearance: White Powder
Purity: 99% Usage: Anti-aging
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β-Nicotinamide mononucleotide / β-NMN Raw Powder CAS 1094-61-7

 

Description:

 

β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+; Item No. 16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.1 At 50-100 µM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.2 Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.

 

Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose and nicotinamide.Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH).

 

Because NADH is a cofactor for processes inside mitochondria, for sirtuins, and for PARP, NMN has been studied in animal models as a potential neuroprotective and anti-aging agent.Dietary supplement companies have aggressively marketed NMN products claiming those benefits,though there is no clinical study on humans published yet.

 

Basic information:


Chemical name: BETA-NICOTINAMIDE MONONUCLEOTIDE
MF: C11H15N2O8P
MW: 334.22
CAS: 1094-61-7
Appearance: white powder
Purity: over 99%


Brief summary about β-NMN:

 

NAD+ exists in all living organisms and is well known as a coenzyme in oxidation−reduction reaction. Recent research has drawn attention to its relation to “sirtuin” represented by NAD+−dependent protein deacetylases such as Sirt1 and Sirt3. Because Sirt1 is reported to regulate various life phenomena as aging, people is especially paying high attention to “Anti-aging effect” associated with the activated sirtuin through Sirtuin/SIRT1−activating components (STACs) as represented by resveratrol. Meanwhile, sirtuin is NAD+−dependent and increase of cellular NAD+ level is expected to have similar effects to the STACs, thus nicotinamide mononucleotide, an intermediate of NAD+ biosynthesis, is also in the spotlight.

 

While absorption of nicotinamide mononucleotide into body and its functional mechanism remain unclear in many respects and are being studied, it is reported that administration tests of nicotinamide mononucleotide into mice show improvement of high fat diet-induced glucose intolerance1), restoration of mitochondrial dysfunction with age2) and reduction of infarct area in response to ischemia/reperfusion3), and that the other chronic administration study in mice indicates rescue effect of age-associated decline in neural stem cells4). Application of nicotinamide mononucleotide for prevention and diagnosis of age-dependent diseases such as diabetes, neurodegenerative disorder, cardiac disease etc. raises high expectation for anti-aging.

 

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Discreet disguised package or as required
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