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C10H13NO2 Phenacetin CAS 62-44-2 Chemical Material Antipyretic Analgesic BP Grade

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C10H13NO2 Phenacetin CAS 62-44-2 Chemical Material Antipyretic Analgesic BP Grade

C10H13NO2 Phenacetin CAS 62-44-2 Chemical Material Antipyretic Analgesic BP Grade
C10H13NO2 Phenacetin CAS 62-44-2 Chemical Material Antipyretic Analgesic BP Grade C10H13NO2 Phenacetin CAS 62-44-2 Chemical Material Antipyretic Analgesic BP Grade

Large Image :  C10H13NO2 Phenacetin CAS 62-44-2 Chemical Material Antipyretic Analgesic BP Grade Get Best Price

Product Details:
Place of Origin: CN
Brand Name: YW
Certification: ISO9001,BRC,KOSHER
Model Number: 62-44-2
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiation
Packaging Details: Discreet package
Delivery Time: 5-8 working days
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 5-8 working days
Detailed Product Description
Product Name: Phenacetin CAS: 62-44-2
MF: C10H13NO2 MW: 179.22
EINECS: 200-533-0 Appearance: White Crystalline Powder
High Light:

local anesthetic powder

,

pain relief powder

 

C10H13NO2 Phenacetin CAS:62-44-2 BP Grade Chemical Material Antipyretic Analgesic,White Powder,99% Purity

 

 

Quick Detail:

 

Phenacetin
CAS: 62-44-2
EINECS Number: 200-533-0
Formula: C10H13NO2
MW: 179.2157
Density: 1.099g / cm3
Melting point: 133-138 ℃
Boiling point: 355.1 ° C at 760 mmHg
Flash Point: 168.5 ° C
Water-soluble: 0.076 g / 100 mL
Vapor Pressure: 3.21E-05mmHg at 25 ° C
Uses: Anti-inflammatory drugs
Assay: 99%
Appearance: White or almost white crystalline powder

 

 

COA:

 

Test Items Specification Test Results
Description Should comply with the standard Pass
Identification Should be positive reaction Pass
  Brownish red 4# Pass
4-chloroacetanilide Should comply with standard Pass
Sulphated ash ≤0.1% 0.06%
Melting point 134ºC to 137ºC 134ºC to 137ºC
Appearance ≥99% 100.58%
Conclusion Complies with BP68 edition


 

Phenacetin description

 

Phenacetin (or acetophenetidin) is a pain-relieving and fever-reducing drug, which was widely used between its introduction in 1887 and the 1983 ban imposed by the FDA on its use in the United States. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized as paracetamol (acetaminophen), which replaced it in some over-the-counter medications following the ban on phenacetin.


It is also called acetophenetidins. Having glossy leaflets or scales-like crystals that have no odor or taste.Melting point 134 ~ 137. Stable in air, soluble in water, slightly soluble in boiling water, slightly soluble in ether, soluble in ethanol, chloroform. It is formed through the etherification,reduction and Acetylation reaction of p-chloronitrobenzene. As chloroacetanilide antipyretic and analgesic agent. Suitable for fever, headache, neuralgia and other drugs as a compound agent.

 
 
 

Applications:


Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)).


It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.


Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C.," or "aspirin-phenacetin-caffeine" compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia.


But the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November of 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.As a result, some branded, and previously phenacetin-based, preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.

Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.


Due to its low cost, phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.

Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.


It is metabolized in the body to paracetamol (acetaminophen), which is also a clinically relevant analgesic.

Phenacetin, and products containing phenacetin, have been shown in an animal model to have the side effect and after-effect of carcinogenesis. In humans, many case reports have implicated products containing phenacetin in urothelial neoplasms, especially urothelial carcinoma of the renal pelvis. In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases.In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis, or dissolution of blood cells, while taking this drug. Acute hemolysis is possible in the case of patients who develop an IgM response to phenacetin leading to immune complexes that bind to erythrocytes in blood. The erythrocytes are then lysed when the complexes activate the complement system.


Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis.This is a condition which results in destruction of some or all of the renal papillae in the kidneys.


One notable death that can possibly be attributed to the use of this drug was that of the aviation pioneer Howard Hughes. He had been using phenacetin extensively for the treatment of chronic pain; it was stated during his autopsy that phenacetin use may have been the cause of his kidney failure.

 

 

Shipping & Delivery


1.Packages are generally dispatched within approximately 2 days after receipt of payment.
2.After the each shipping we will provide you with:
1) tracking number to track your package online.
2) the few pictures with your order & details.
3.About the Custom clearance,we packed in disguise ways.In our experience,the appropriate and safe delivery,there won't be problems.
4.We confirm 99% clearance.
5.Is it the best & safest shipping for all our repeat customers!


Packing Details


Discreet packing ways as your requirement, 99% go through.

 

Storage


Store in cool and dry area and keep away from direct sunlight.

 

MOQ


We accept any Qty you require, grams to kilograms.

 

Order infos


Payment Methods:West Union,Moeny Gram, Bitcoin and Bank Transfer.
Delivery Ways:EMS,HKEMS,TNT,DHL,FedEX,UPS etc.
Shipment Time:Within 12 hours after confirmation of your payment
Other Service:Safe shipment,high purity and best price for you.

 

 

 

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