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Antipyretic and Analgesic Phenacetin Pharmaceutical Garde For Pain - Relieving And Fever - Reducing

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Antipyretic and Analgesic Phenacetin Pharmaceutical Garde For Pain - Relieving And Fever - Reducing

Antipyretic and Analgesic Phenacetin Pharmaceutical Garde For Pain - Relieving And Fever - Reducing
Antipyretic and Analgesic Phenacetin Pharmaceutical Garde For Pain - Relieving And Fever - Reducing Antipyretic and Analgesic Phenacetin Pharmaceutical Garde For Pain - Relieving And Fever - Reducing

Large Image :  Antipyretic and Analgesic Phenacetin Pharmaceutical Garde For Pain - Relieving And Fever - Reducing Get Best Price

Product Details:
Place of Origin: CN
Brand Name: YW
Certification: ISO9001,BRC,KOSHER
Model Number: 62-44-2
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiation
Packaging Details: Discreet package
Delivery Time: 5-8 working days
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 5-8 working days
Detailed Product Description
Product Name: Phenacetin CAS: 62-44-2
MF: C10H13NO2 MW: 179.22
EINECS: 200-533-0 Appearance: White Crystalline Powder
High Light:

local anesthetic powder

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local anesthetic drugs

 
 
Antipyretic and Analgesic Phenacetin Pharmaceutical Garde, For Pain-Relieving And Fever-Reducing,CAS:62-44-2
 
 
Phenacetin Basic information
 
Name: Phenacetin
CAS No.: 62-44-2
Formula: C10H13NO2
Molecular Weight: 179.24
Synonyms: p-Acetophenetidide(8CI);4-(Acetylamino)phenetole;4-Ethoxy-1 acetylaminobenzene; 4-Ethoxyacetanilide; 4'-Ethoxyacetanilide; Aceto-4-phenetidine; Acetophenetidin; Acetophenetidine; Acetophenetin; Acetphenetidin; Fenidina; Fenina;Kalmin;N-(4-Ethoxyphenyl)acetamide;N-Acetyl-4-ethoxyaniline; N-Acetyl-p-ethoxyaniline;N-Acetyl-p-phenetidine;NSC 7651; Pertonal; Phenacetin; Phenacetine; Phenazetin; Phenedina; Phenidin; Phenin;p-Ethoxyacetanilide;
EINECS: 200-533-0
Density: 1.099 g/cm3
Melting Point: 133-136 °C(lit.)
Boiling Point: 355.1 °C at 760 mmHg
Flash Point: 168.5 °C
Solubility: 0.076 g/100 mL in water
Appearance: white crystalline powder
 
 
Description
 
 
Phenacetin, and products containing phenacetin, have been shown in an animal model to have the side effect and after-effect of carcinogenesis. In humans, many case reports have implicated products containing phenacetin in urothelial neoplasms, especially urothelial carcinoma of the renal pelvis. In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases.In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis, or dissolution of blood cells, while taking this drug. Acute hemolysis is possible in the case of patients who develop an IgM response to phenacetin leading to immune complexes that bind to erythrocytes in blood. The erythrocytes are then lysed when the complexes activate the complement system.
Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis.This is a condition which results in destruction of some or all of the renal papillae in the kidneys.
One notable death that can possibly be attributed to the use of this drug was that of the aviation pioneer Howard Hughes. He had been using phenacetin extensively for the treatment of chronic pain; it was stated during his autopsy that phenacetin use may have been the cause of his kidney failure.
 
 
 
Applications:
 
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)).
 
It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.
 
Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.
 
 
 
 
COA:
 
 
Product Phenacetin CAS No. 62-44-2
Quantity 1000KG Testing date 20181120
Test Standard BP68 Expiry date 3 years
Items Specifications Results
Description White or off-white crystalline powder Conforms
Identification Positive Positive
Melting point 134°C to 136.5°C 134.5-136.5°C
4-chloroacetanilide BP1968 <3.5ml/0.6g
P-Phenetidine BP1968 Conforms
Sulphated ash ≤0.1% 0.07%
Assay ≥99% 99.1%
Through a uss#80 ≥90% 98%
Conclusion This batch comlies with BP68 Standard
 
 
 
Safety:
 
 
Phenacetin, and products containing phenacetin, have been shown in an animal model to have the side effect and after-effect of carcinogenesis. In humans, many case reports have implicated products containing phenacetin in urothelial neoplasms, especially urothelial carcinoma of the renal pelvis. In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases.In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis, or dissolution of blood cells, while taking this drug. Acute hemolysis is possible in the case of patients who develop an IgM response to phenacetin leading to immune complexes that bind to erythrocytes in blood. The erythrocytes are then lysed when the complexes activate the complement system.
 
Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis.This is a condition which results in destruction of some or all of the renal papillae in the kidneys.
 
One notable death that can possibly be attributed to the use of this drug was that of the aviation pioneer Howard Hughes. He had been using phenacetin extensively for the treatment of chronic pain; it was stated during his autopsy that phenacetin use may have been the cause of his kidney failure.
 
 
 
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Good quality is one secret for our success. All of our products enjoys high purity. Thus, it can make sure our client's need. Welcome order the samples, MOQ just 10 grams.
 
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We have mass stock, so that we can arrange the delivery within 24hours once receiving the payment. Tracking number would be informed quickly after shipment. We have our own way of packing which could ship 0.01 kilo to 50 kilo products a time.
 
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24/7 is available. We will tell you the package updated info ASAP. And try our best to solve various problems customers encountered!
 
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Besides raw steroid powder and liquid, we offer hormone solution and formula. We can teach you how to make hormone solution on the site. Any visit to our lab is welcomed.
 
 
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