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Antihistamine drug Cyproheptadine Hydrochloride White Powder CAS: 41354-29-4
Cyproheptadine Hydrochloride is the hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain.
Chemical name: Cyproheptadine hydrochloride
Appearance: white powder
Purity: over 99%
|Product name||Cyproheptadine HCL|
|CAS No.||41354-29-4||Outer Packing||1KG/bag|
|Production date||2013.09.04||Shelf life||2016.09.03|
|Items of analysis||Specification||Results|
|APPEARANCE||A white or slightly yellow,odorlessor practicallyodorless,crystalline powder.||Complies|
|IDENTIFICATION||The IR spectrum of the preparation of test||Complies|
|ACIDITY(0.05% as HCL,ml)||Not more than 0.15ml||0.13ml|
|RESIDUE ON IGNITION||≤0.1%||0.06%|
|ASSAY||C 21 H 21 N,HCl not less than 98.5%||99.61%|
Periactin (cyproheptadine) 4 mg tablets
Cyproheptadine is used to treat allergic reactions (specifically hay fever).The evidence for its use for this purpose in children is weak and ketotifen and loratadine showed equal or better results in the small trials in which they have been compared.
It is sometimes used, especially in its liquid formulation, as a preventive measure against migraine in children and adolescents,but as of 2017 the evidence for this was weak.This use is on the label in the UK and some other countries.
It is also used off-label in the treatment of cyclical vomiting syndrome in infants; the only evidence for this use comes from retrospective studies.
Cyproheptadine is sometimes used off-label to improve akathisia in people on antipsychotic medications.
It used off-label to treat various dermatological conditions, including psychogenic itch drug-induced hyperhidrosis (excessive sweating),and prevention of blister formation for some people with epidermolysis bullosa simplex.
One of the effects of the drug is increased appetite and weight gain, which has led to its use (off-label in the USA) for this purpose in children who are wasting as well as people with cystic fibrosis.The evidence for the efficacy in light of other side effects is weak.
It is sometimes used off-label in the management of moderate to severe cases of serotonin syndrome, a complex of symptoms associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors and monoamine oxidase inhibitors), and in cases of high levels of serotonin in the blood resulting from a serotonin-producing carcinoid tumor.
How to use Cyproheptadine HCL:
Take this medication by mouth with or without food as directed by your doctor, usually 2 to 3 times a day. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
The dosage is based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight and body size. Do not increase your dose or take this medication more often than directed.
Tell your doctor if your condition does not improve or if it worsens.
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