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|Appearance:||White Powder||Assay:||Over 99%|
|Usage:||Anticonvulsant Drug||CAS Number:||148553-50-8|
local anesthetic powder,
pain relief powder
Anticonvulsant Drug Pregabalin CAS:148553-50-8 White Powder
Pregabalin is an anticonvulsant drug used for neuropathic pain, epilepsy and generalized anxiety disorder.It presents antihyperalgesic actions by binding to the α2δ subunit of the voltage-dependent calcium channels without presenting antinociceptive actions. Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release).It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S.
Chemical name: Pregabalin
Appearance: White powder
Purity: Over 99%
Usage: anticonvulsant drug
Pregabalin works in different ways:
in epilepsy it stops seizures by reducing the abnormal electrical activity in the brain
with nerve pain it blocks pain by interfering with pain messages travelling through the brain and down the spine
in anxiety it stops your brain from releasing the chemicals that make you feel anxious
Pregabalin is only available on prescription. It comes as capsules or a liquid that you drink.
|CAS No.||148553-50-8||Outer Packing||25KG/Cardboard Drum|
|Production date||2017.6.17||Shelf life||2 years|
|Standard adopted||company standard|
|Items of analysis||Specification||Results|
|Loss on drying||
|Related Substances||Any single impurity ≤0.1% otal impurity ≤0.8%||
|Purity By HPLC R-isomer||
|Residue on ignition||
Pregabalin is useful when added to other treatments, when those other treatments are not controlling partial epilepsy.Its use alone is less effective than some other seizure medications.It is unclear how it compares to gabapentin for this use.
The European Federation of Neurological Societies recommends pregabalin as a first line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain.A minority obtain substantial benefit, and a larger number obtain moderate benefit.Other first line agents, including gabapentin and tricyclic antidepressants, are given equal weight as first line agents, and unlike pregabalin, are available as less expensive generics.
Pregabalin is not recommended for certain other types of neuropathic pain such as trigeminal neuralgia and its use in cancer-associated neuropathic pain is controversial. There is no evidence for its use in the prevention of migraines and gabapentin has been found not to be useful.It has been examined for the prevention of post-surgical chronic pain, but its utility for this purpose is controversial.
Pregabalin is generally not regarded as efficacious in the treatment of acute pain.In trials examining the utility of pregabalin for the treatment of acute post-surgical pain, no effect on overall pain levels was observed, but people did require less morphine and had fewer opioid-related side effects.Several possible mechanisms for pain improvement have been discussed.
The World Federation of Biological Psychiatry recommends pregabalin as one of several first line agents for the treatment of generalized anxiety disorder, but recommends other agents such as SSRIs as first line treatment for obsessive-compulsive disorder and post-traumatic stress disorder.It appears to have anxiolytic effects similar to benzodiazepines with less risk of dependence.
The effects of pregabalin appear after 1 week of use and is similar in effectiveness to lorazepam, alprazolam, and venlafaxine, but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychosomatic anxiety symptoms. Long-term trials have shown continued effectiveness without the development of tolerance, and, in addition, unlike benzodiazepines, it has a beneficial effect on sleep and sleep architecture, characterized by the enhancement of slow-wave sleep.It produces less severe cognitive and psychomotor impairment compared to those drugs; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.
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