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Domperidone Raw Powder CAS: 57808-66-9 Effective Anti-emetic Medicine
Chemical name: Domperidone
Purity: over 99%
Appearance: white powder
|Product name||Domperidone BP|
|CAS No.||57808-66-9||Outer Packing||25KG/DRUM|
|Production date||Shelf life|
|Items of analysis||Specification||Results|
|Appearance||white or almost white powder||white powder|
|solubility||practically insoluble in water,soluble in dimethyl formanide,slightly soluble in ethanol(96%) and in methanol.||complies|
|A.melting point||244.0 ℃-248.0℃||246.0 ℃-247.1℃|
|B.by IR||IR spectrum of test sample should match with IR spectrum of working standard.||complies|
|C.by TLC||the principal spot in the chromatogram obtained with the test solution in similar in position and size to the principal spot in the chromatogram obtained with reference solution(a).||complies|
|appearance of solution||the solution should be clear and not more intensely colored than reference solution Y6||Meets the requirement|
|Impurity -A||Not more than 0.25%||0.09%|
|Impurity-B||Not more than 0.25%||Not detected|
|Impurity-C||Not more than 0.25%||Not detected|
|Impurity-D||Not more than 0.25%|
|Impurity-E||Not more than 0.25%||Not detected|
|Impurity-F||Not more than 0.25%||Not detected|
|Unspicified impurities||Not more than 0.10%||0.07%|
|total impurities||Not more than 0.5%||0.15%|
|heavy metals||Not more than 20ppm||less than 20 ppm|
|loss on drying||Not more than 0.5%||0.43%|
|sulphate ash||Not more than 0.1%||0.04%|
|assay on chemical(on dried basis)||99.0%-101.0% w/w||99.7% w/w|
|particl size(malvern particle size analyzer)||d90-not less than 400;d50-not later than 300||meets the requirement|
Domperidone, sold under the brand name Motilium among others, is a peripherally selective dopamine D2 receptor antagonist that was developed by Janssen Pharmaceutica and is used as an antiemetic, gastroprokinetic agent, and galactagogue.It may be administered orally or rectally, and is available in the form of tablets, orally disintegrating tablets (based on Zydis technology),suspension, and suppositories.The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasing gastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin.
Generally, we start with 30 mg (three 10 mg tablets) three times per day - a total of 9 tablets per day. In some situations we will go as high as 40 mg four times per day (or, for convenience, 60 mg once per day and 50 mg twice per day). The pharmacist may instruct you to take each does 30 minutes before eating, but that is because of its usual use for digestive problems. Taking domperidone on an empty stomach does allow it to be better absorbed, but it is not necessary to do this for it to work to increase breastmilk production. Spread the doses out throughout the day and take it when it is most convenient for you.
After starting domperidone, it often takes three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer. It may also be important to remember that domperidone usually only begins to work three or four weeks after birth, but sometimes earlier. Sometimes the herbal remedies work best early on.
How to take domperidone:
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about domperidone and will provide you with a full list of the side-effects which you may experience from taking it.
Take domperidone exactly as your doctor tells you to. The dose for adults and for young people aged over 16 years is 10 mg (one tablet) up to three times a day. Do not take more than three doses in any 24-hour period. If it has been prescribed for a child, the dose will be printed on the label of the pack to remind you what the doctor said.
Take your doses about half an hour before meals. If you take domperidone after a meal, it will still work, but it may take longer to have an effect.
Domperidone should be taken for a short period of time only. Your treatment will last no longer than seven days.
The usual dose of domperidone is 10 milligrams up to three times a day.
Always take your domperidone exactly as your doctor has told you.
The pharmacy label on your medicine will tell you how much domperidone to take, how often to take it, and any special instructions.
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