|Place of Origin:||China|
|Certification:||GMP, ISO9001, USP, KOSHER|
|Minimum Order Quantity:||100 grams|
|Packaging Details:||Discreet disguised package or as required|
|Delivery Time:||3~7 working days|
|Payment Terms:||Western Union, Moneygram, Bitcoin and Bank Wire Transfer|
|MW:||300.44||Usage:||For Treating Severe Cystic Acne|
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Isotretinoin / accutane Yellow Powder CAS: 4759-48-2 for Treating Severe Acne
Isotretinoin is a medication used for the treatment of severe acne. It is sometimes used in prevention of certain skin cancers. It is a retinoid, meaning it derives from vitamin A and is found in small quantities naturally in the body. Isotretinoin binds to and activates nuclear retinoic acid receptors (RAR), thereby regulating cell proliferation and differentiation. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
Appearance: Yellow or orange crystalline powder
Usage: for treating severe cystic acne
|CAS No.||4759-48-2||Outer Packing||100G|
|Production date||2017.12.03||Shelf life||2019.12.02|
|Items of analysis||Specification||Results|
|Description||Yellow or orange crystalline powder||complies|
|Loss on drying||Not more than 0.5%||0.04%|
|Residue on ignition||Not more than 0.1%||0.02%|
|Heavy metals||Not more than 0.002%||＜0.002|
|Tretinoin||Not more than 1.0%||0.1%|
Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments.Many dermatologists also support its use for treatment of lesser degrees of acne that prove resistant to other treatments, or that produce physical or psychological scarring.Isotretinoin is not indicated for treatment of prepubertal acne and is not recommended in children less than 12 years of age.
It is also somewhat effective for hidradenitis suppurativa and some cases of severe acne rosacea.It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer.
Isotretinoin therapy has furthermore proven effective against genital warts in experimental use, but is rarely used for this indication as there are more effective treatments. Isotretinoin may represent an efficacious and safe alternative systemic form of therapy for recalcitrant condylomata acuminata (RCA) of the cervix. In most countries this therapy is currently unapproved and only used if other therapies failed.
What is the usual dose of isotretinoin?
The range of doses used each day for acne is less than 0.1 to over 1 mg/kg body weight. Some patients may only need a small dose once or twice a week. A course of treatment may be completed in a few months or continue for several years. For acne, some prescribers have targeted a total cumulative dose of 120-140 mg/kg, in the hope of reducing relapse, but the evidence for this remains controversial. The general trend has been to use lower dosages, unrelated to body weight (eg 10 mg/day).
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