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|Purity:||99%||Appearance:||White Crystalline Powder|
|CAS Number:||2180-92-9||Usage:||Local Anesthetics|
pain relief powder,
local anesthetic drugs
Local Anesthetics Bupivacaine CAS 2180-92-9 White Powder 99% Purity
Bupivacaine is only found in individuals that have used or taken this drug. It is a widely used local anesthetic agent. [PubChem]Bupivacaine blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Bupivacaine binds to the intracellular portion of sodium channels and blocks sodium influx into nerve cells, which prevents depolarization. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: pain, temperature, touch, proprioception, and skeletal muscle tone. The analgesic effects of Bupivicaine are thought to potentially be due to its binding to the prostaglandin E2 receptors, subtype EP1 (PGE2EP1), which inhibits the production of prostaglandins, thereby reducing fever, inflammation, and hyperalgesia.
Chemical name: BUPIVACAINE
Appearance: white powder
Purity: over 99%
Bupivacaine is indicated for local infiltration, peripheral nerve block, sympathetic nerve block, and epidural and caudal blocks. It is sometimes used in combination with epinephrine to prevent systemic absorption and extend the duration of action. The 0.75% (most concentrated) formulation is used in retrobulbar block. It is the most commonly used local anesthetic in epidural anesthesia during labor, as well as in postoperative pain management.Liposomal formulations of buipivacaine are no more effective than plain solutions of bupivacaine.
Action: How Bupivacaine Injection works:
Bupivacaine, like other local anaesthetics, causes a reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the nerve membrane. Local anaesthetics of the amide type are thought to act within the sodium channels of the nerve membrane.
Bupivacaine Injection contains bupivacaine hydrochloride BP (0.25% or 0.5%). It also contains sodium chloride and water for injections.
This medicine does not contain a preservative.
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