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|CAS:||317318-70-0||Character:||Off- White Powder|
GW 501516 SARMS Bodybuilding Supplements CAS 317318-70-0 Cardarin For Fat Loss
Other name: GSK-516, Endurobol
CAS No.: 317318-70-0
Other Name: GSK-516,Endurobol
Melting Point: 173-179ºC
Boiling Point: 584.543ºC at 760mmHg
Appearance: White fine powder
Payment terms:T/T , Western Union , Money Gram ,Bitcoin
Usage: It had been investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. GW501516 could be used by athletes as an ergogenic performance enhancing drug.The most common use of GW consists of the extreme amount of endurance and recovery increase. The other main use of GW-501516 is to aid in fat loss. GW-501516 has shown to melt away fat at a rapid pace.
GW 501516 is a drug that acts as a PPARd modulator. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions, especially when used in conjunction with a synergistic compound AICAR, as the combination has been shown to significantly increase exercise endurance in animal studies. GW-50156 regulates fat burning through a number of widespread mechanisms; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization. This shift changes the body’s metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity.
There are two main uses with GW-501516. The first and most common use is that of increased endurance. GW has been banned for professional athletes due to the unfair advantage it provides to endurance athletes. Anyone want a drastic increase in endurance will find that GW truly shines in this aspect. It takes effect very quickly and the results can be staggering. A common dose of 10 mg day will provide a significant increase in endurance.
The second common usage with GW is that of fat loss. Many users turn to GW as it has shown to melt off fat while still being non-catabolic. You will find that you can still hold on to some muscle as you are losing fat. It helps when you are running it in conjunction with SARMS Ostarine and S4, to hold on to as much muscle as possible. A dosage of 10 mg a day will provide good amounts of fat loss, but an increase to 20 mg a day will provide much more in this area.
GW 501516 can be ran in 8 week cycles, but as with any other steroid or supplement, it should be cycled properly to avoid any possible side effects and the keep it as effective as possible.
|Description||: White Crystalline Powder||White Crystalline Powder|
|Assay(by HPLC)||: 98.0~102.0%||99.84%|
|Melting Point||: 191~195℃||193.5~195.0℃|
|Loss On Drying||: 0.5%max||0.19%|
|Specific Rotation||: +288℃~ +298℃||+290.2℃|
|Residue On Ignition||: 0.1%max||0.03%|
|Related Substances||: Total:1.5%max||<1.3%|
|Residue Solvents||: 0.2%max||0.10%|
|Heavy Metals||: 20PPm max||<10PPm|
|Conclusion||The specification conform with enterprise standard.|
5.How it works?
ENDUROBOL is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ.
It activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions, especially when used in conjunction with a synergistic compound AICAR, as the combination has been shown to significantly increase exercise endurance in human.
GW501516 (also known as GW-501,516, GW1516, GSK-516 and Endurobol)is a PPAR receptor.
It activates the same pathways activated through exercise, including PPAR and AMP-activated protein kinase. It had been investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. GW501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound .
An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist.
Exhibits selectivity for PPARo compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.
When you are taking GW-501516 it is very important that you take the right dose and at the right time. Of course, if you take between 10mg and 20mg a day then this is a great way for you to start seeing results and the main reason for this is because 10mg is aimed at those who want to get a higher level of endurance and if you do boost up the dosage then you will certainly get the better results in terms of the fat loss that you have. If you take a look at the lab mice study then you will be taking it 45 minutes before you do start exercise so it has plenty of time for you to get the product to work. GW-501516 also underwent a 2-year study and this showed that there were no increases or even any decreases in terms of the stagnation effects. A lot of people can run GW-501516 for a total of 12 or 14 weeks and they only need a 4 week break before they then go and start taking it again. Of course, you may want to run this with a SARM cycle because when you do this you know that you can get the best results from your workout. At the end of the day, GW-501516 was meant to be taken over a long period of time and this alone makes it ideal for you to use over the time you need. Of course, the half-life of this is between 16 or 24 hours and you should take 10mg every 10 hours if you are on a higher dose. You do not need to run PCT when you are on this but it is recommended that you take GW-501516 alongside PCT if you know that you have been using anabolic products that have a high level of toxicity.
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