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Articaine Hydrochloride Articaine HCL CAS 23964 57 0 For Pain Relief Pharmaceutical Grade

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Articaine Hydrochloride Articaine HCL CAS 23964 57 0 For Pain Relief Pharmaceutical Grade

China Articaine Hydrochloride Articaine HCL CAS 23964 57 0 For Pain Relief Pharmaceutical Grade supplier
Articaine Hydrochloride Articaine HCL CAS 23964 57 0 For Pain Relief Pharmaceutical Grade supplier Articaine Hydrochloride Articaine HCL CAS 23964 57 0 For Pain Relief Pharmaceutical Grade supplier

Large Image :  Articaine Hydrochloride Articaine HCL CAS 23964 57 0 For Pain Relief Pharmaceutical Grade

Product Details:

Place of Origin: China
Brand Name: LSW
Certification: GMP, ISO9001, USP, KOSHER
Model Number: 23964-57-0

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: Discreet package or as required
Delivery Time: 3~5 working days
Payment Terms: Western Union, Moneygram, Bitcoin and Bank wire transfer
Supply Ability: 5000kg/week
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Detailed Product Description
Usage: Pain Killer/Relief CAS: 23964-57-0
Assay: 98% Min. Delivery: Express Courier.
Character: White Or Almost White Crystalline Powder MF: C13H20N2O3S.HCl

99% High Purity Articaine Hydrochloride Articaine HCL CAS 23964 57 0 For Pain Relief Pharmaceutical Grade

 

Description:

 

Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia.

 

In comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like lidocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity. Articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations.


Quick details:

 

Product Name: Articaine hydrochloride / Articaine HCL
Articaine HCL CAS No.: 23964-57-0
Articaine HCL Formula: C13H20N2O3S.HCl
Articaine HCL Molecular Weight: 320.84
Synonyms: Articaine HCL;2-Thiophenecarboxylicacid, 4-methyl-3-[2-(propylamino)propionamido]-, methyl ester,monohydrochloride (8CI);2-Thiophenecarboxylic acid,4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-, methyl ester,monohydrochloride (9CI);Carticain;Carticainechlorhydrate;Carticaine hydrochloride;Methyl4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylatehydrochloride;Septanest;Ubistesine;Ultacain;Ultracain;Ultracaine;
Articaine HCL EINECS: 245-957-7
Articaine HCL Boiling Point: 440.6 °C at 760 mmHg
Flash Point: 220.3 °C
Articaine HCL Appearance: white powder
Min.Order: 1Kg Aarticaine HCL Available
Packing: Aluminum Foil Bag or Fiber Drum(1Kg, 25Kg)
Delivery Method: HKEMS, DHL, TNT, UPS, FEDEX, EMS etc. By air or by Sea.
Delivery Time: 5-14 Working Days, Tracking Number Available
Payment Terms: T/T, MoneyGram, Western Union and Bitcoin
Origin: Hubei Province, China
Brand Name: YUANCHENG PHARMACEUTICAL
Production Capacity: Articaine HCL 500Kg/Month


Application:

 

1. Structure and Metabolism
The amide structure of articaine is similar to that of other local anesthetics, but its molecular structure differs through the presence of a thiophene ring instead of a benzene ring. Articaine is exceptional because it contains an additional ester group that is metabolized by esterases in blood and tissue. The elimination of articaine is exponential with a half-life of 20 minutes. Since articaine is hydrolized very quickly in the blood, the risk of systemic intoxication seems to be lower than with other anesthetics, especially if repeated injection is performed.

 

Articaine is a local anaesthetic that has been approved overseas for several years. Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve. This action is prolonged by combining the drug with a vasoconstrictor such as adrenaline.

 

The combination of articaine and adrenaline can be used for local or regional anaesthesia for dental procedures. Anaesthesia begins within six minutes and lasts for an hour. The half-life of articaine is approximately 1.8 hours. It is metabolised and then mainly excreted in the urine.

 

2. Clinical use
(1) Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.


(2) In dentistry, articaine is used both for infiltration and block injections, with the block technique yielding the greatest duration of anesthesia.


(3) In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaine works well.

 


COA:

 

Articaine Hydrochloride Articaine HCL CAS 23964 57 0 For Pain Relief Pharmaceutical Grade

 

 

Functions:

 

Articaine blocks nerve conduction by reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent: it has the highest affinity for the open state, an intermediate affinity for the inactivated state, and the lowest affinity for the resting state.

The degree of neuronal block is affected by the diameter of the nerve. Larger-diameter fibers (touch/pressure/ motor) require higher concentrations of local anesthetic compared with small myelinated fibers (pain afferents).Articaine is lipid soluble, highly protein-bound (94%), and has a dissociation constant (pKa) of 7.8. Articaine is an intermediate-potency, short-acting local anesthetic with a fast onset of action.


Usage and Dosage:

 

Local infiltration or nerve block anesthesia, oral submucosal injection.Before pumping the blood back to check whether the blood vessels,especially nerve block anesthesia.The injection rate should not exceed 1 ml/min.Adults:The appropriate dose must be administered according to the needs of the operation.For general surgery,usually given dose of 1/2 to 1 or compliance.The maximum dose of articaine hydrochloride should not exceed 7 mg/kg body weight.Children over 4 years of age: different doses must be used depending on the age,weight,and type of operation of the child.The maximum dose of articaine hydrochloride does not exceed 5 mg/kg body weight.The average dose for children receiving orally taking orally is calculated in milligrams as follows:Weight of child (kg) x1.33 Older:Half of adult dose.

 

Articaine Hydrochloride Articaine HCL CAS 23964 57 0 For Pain Relief Pharmaceutical Grade

 
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2) All Purity:>=99%
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