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99% Purity Pharmaceutical Intermediates Local Anesthetic Pain Killer Powder Procaine CAS 59 46 1

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99% Purity Pharmaceutical Intermediates Local Anesthetic Pain Killer Powder Procaine CAS 59 46 1

China 99% Purity Pharmaceutical Intermediates Local Anesthetic Pain Killer Powder Procaine CAS 59 46 1 supplier
99% Purity Pharmaceutical Intermediates Local Anesthetic Pain Killer Powder Procaine CAS 59 46 1 supplier 99% Purity Pharmaceutical Intermediates Local Anesthetic Pain Killer Powder Procaine CAS 59 46 1 supplier

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Product Details:

Place of Origin: China
Brand Name: LSW
Certification: GMP, ISO9001, USP, KOSHER
Model Number: 59-46-1

Payment & Shipping Terms:

Minimum Order Quantity: 10 grams
Price: Negotiable
Packaging Details: Discreet disguised package or as required
Delivery Time: 3~7 working days
Payment Terms: Western Union, Moneygram, Bitcoin and Bank Wire Transfer
Supply Ability: 5000kg/week
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Detailed Product Description
Appearance: White Powder Assay: Over 99%
Usage: Local Anesthetic Drug CAS Number: 59-46-1
MF: C13H20N2O2 MW: 236.31

99% Purity Pharmaceutical Intermediates Local Anesthetic Pain Killer Powder Procaine CAS 59 46 1
 
 
1.Quick detail:
 
Product Name: Procaine
CAS: 59-46-1
Grade: pharmaceutical grade
Assay: 99%
MF: C13H20N2O2
MW: 236.3101
EINECS: 200-426-9
Appearance: white crystalline
Packing: 25KG/ cardboard bucket can be split
Ingredients: 4- amino benzoic acid -2- (two ethyl amino) ethyl ester
Physical and chemical properties: white or white crystalline powder
Category: pharmaceutical raw materials
Field: local anesthesia
Application: for local anesthesia, used in the eyes, ears, nose, teeth and other operations, for infiltration anesthesia, transmission tutor anesthesia and blocking therapy
 
 
2.Description:
 
Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as Procaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
 
Procaine was first synthesized in 1905, shortly after amylocaine. It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Procaine, from the Latin nov- (meaning new) and -caine, a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, was the most commonly used local anesthetic.[citation needed] Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this[why?] and spent many years touring dental schools to advise them not to use it.
 
 
3.Application:
 
Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.
 
Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase,[citation needed] which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.
 
 
4.Usage:
 
Procaine is a kind of local anesthetics. With low toxicity but quick and safe effects, procaine is suitable for local anesthesia, applied to the eye, ear, nose, teeth and other department operation, used for infiltration anesthesia, anesthesia and closed therapy supervisor. Procaine is also used in the production of procaine penicillin.Procaine causes loss of feeling (numbness) of skin and mucous membranes. Procaine is used as an injection during surgery and other medical and dental procedures.
 
Procaine application before removal of a decayed toothThe primary use for procaine is as an anaesthetic.
Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction.
 
Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.
 
Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.
 
Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.
 
A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10ml of 1% procaine), as it helps relieve pain and vascular spasm.
 
 
5.COA:
 
Test Items Specification Test Results
Appearance White crystals or a white crystalline powder Conform
Identification ABE. It appears positive reaction
Melting point 154degree~158degree 154degree~157degree
Acidity PH 5.0~6.5 PH=5.9
Appearance of solution Clear and colourless Conform
Loss on drying ≤0.5% 0.07%
Heavy metals ≤0.0005% Conform
Related substances ≤0.05% Conform
Sulphated ash ≤0.1% 0.05%
Assay ( on dry basis ) 99.0-101.0% 99.87%
Conclusion Conform to BP2005
 
 
6.Side effect:
 
Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.[8] Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.
 
Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 white North Americans are homozygotic (i.e. they have two copies of the abnormal gene) for the commonest atypical form of the enzyme pseudocholinesterase,[10] which means that they do not hydrolyze ester anesthetics such as procaine. The results in a prolonged period of high levels of the anesthetic in the blood and increased toxicity. However, there are populations in the world, such as the Vysya community in India, where deficiency of this enzyme is much more common.
Proceeding your order
 
 
7.Function:
 
A local anesthetic of the amino ester group that is primarily used as a topical anesthetic.Also used to control the pain of intramuscular injection of penicillin as well as in dentistry.Non Caine local anesthetic.
Procaine hydrochloride is a kind of local anesthetics, for local anesthesia, nerve block etc, can block the conduction of nerve fibers with anesthetic effect, strong function, low toxicity, and no addiction, but the skin, mucous membrane penetration force is weak, not suitable for surface anesthesia, clinically used to infiltration, spine and conduction anesthesia.
 
 
8.Our adwantage:
 
(1) High quality with competitive price:
 
1) Standard: Enterprise Standard;
 
2) All Purity≥98%;
 
3) We are manufacturer and can provide high quality products with factory price.
 
(2) Fast and safe delivery:
 
1) Parcel can be sent out within 24 hours after payment. Tracking number available;
 
2) Secure and discreet shipment. Various transportation methods for your choice;
 
3) Customs pass rate ≥99%;
 
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
 
(3) We have clients throughout the world:
 
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire;
 
2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility;
 
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
 
 
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10.Contact:
 
Wendy
 
Email:Wendy@chembj.com
 
WhatsApp:+8618872220733
 
Do not hesitate to contact me if you are interested in or have any other questions ,requirment. All welcome!
 
99% Purity Pharmaceutical Intermediates Local Anesthetic Pain Killer Powder Procaine CAS 59 46 1
 

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