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|CAS:||863288-34-0||Synonyms:||Mod GRF 1-29, CJC-1295 No DAC,CJC-1295 Without DAC, CJC 1295 W/o DAC|
|Appearance||White Lyophilized Powder|
|Unit Size||5mg per vial|
|Delivery time||Within 18 hours upon receipt of payment|
|Delivery||EMS, DHL, TNT, FedEx, UPS etc|
|Storage||Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.|
|Usage||inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptides|
1. Selank is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is a synthetic analogue of a human tetrapeptide tuftsin.
2. Selank is a synthetic analogue of the immunomodulatory peptide tuftsin; as such, it mimics many of its effects. It has been shown to modulate the expression of Interleukin-6 (IL-6) and affect the balance of T helper cell cytokines. It has been shown to influence the concentration of monoamine neurotransmitters and induce metabolism of serotonin. There is evidence that it may also modulate the expression of brain-derived neurotropic factor (BDNF) in rats.
3. Selank, as well as a related peptide drug, semax, have been found to inhibit enzymes involved in the degra
4. While Selank is classified as a nootropic-anxiolytic type drug, it uses extend beyond the relief of anxiety and improved cognitive functioning alone. A few areas in which Selank may find itself useful are: Stress reduction, the alleviation of depression, reversal of anhedonia, improvement in mood in emotionally stable individuals, and cessation of insomnia. Of course, with Selank being a nootropic-anxiolytic, it may also prove useful for the treatment of different forms of anxiety, such as G. A. D (generalized anxiety disorder), S. A. D (social anxiety disorder), Panic Disorder, as well as non-diagnosed bouts of anxiety. As a nootropic, Selank can help enhance mental sharpness, reduce mental fatigue, improve the ability to focus, improve cognitive functioning while in a sleep deficit, and enhance memory.
5. These effects are provided without the negative side effects typically associated , such as physical dependence, psychological addiction, and decreased motor ability. In fact, Selank is largely devoid of side effects, with the large majority of researchers claiming that it is a "side effect free" compound. This makes Selank more suitable for long-term use.
|Test Items||Specification||Test Results|
|Description||White or almost white crystalline powder||White crystalline powder|
|Loss of drying||≤1.0%||0.5%|
|TLC||Only one spot||Only one spot|
|Conclusion||It complies with the USP 32.|
Selank's Mechanism of Action:
Selank appears to exert its effects through dopamine, serotonin and norepinephrine modulation while also having potent effects on the immune system.
A rodent study showed a 0.3mg/kg injection of Selank was able to increase norepinephrine and serotonin in various regions of the brain, including the hippocampus and frontal cortex
A similar study noted an increase of serotonin metabolism in the hypothalamus 30-120 minutes after 0.3mg/kg injection into rodents
A third study demonstrated selank was able to prevent hypoxia induced decreases in serotonin and norepinephrine, which preserved normal behavior
Interestingly, when compared directly to tuftsin, the endogenous peptide that selank is based upon, selank would appear superior. A rodent study which sought to block the synthesis of serotonin with p-chlorophenylalanine saw enhanced serotonin levels with selank administration but no result with tuftsin. Clearly the PGP “tail” addition to the molecule somehow enhances its effects.
Selank as an antiviral agent
Selank neuropeptide also expresses immunomodulatory effects. In 2009 a study by F. Ershov et all. has evaluated antiviral properties of Selank both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2). The pronounced antiviral effect of Selank was detected in both systems. The highest efficiency - completely supressed viral reproduction was shown when Selank was added to the cell culture 24 hours before inoculation.
Experimental and clinical studies showed the following pharmaclogical effects of Selank:
1.While Selank is classified as a nootropic-anxiolytic type drug, it uses extend beyond the relief of anxiety and improved cognitive functioning alone. A few areas in which Selank may find itself useful are: Stress reduction, the alleviation of depression, reversal of anhedonia, improvement in mood in emotionally stable individuals, and cessation of insomnia.
2.Of course, with Selank being a nootropic-anxiolytic, it may also prove useful for the treatment of different forms of anxiety, such as G. A. D (generalized anxiety disorder), S. A. D (social anxiety disorder), Panic Disorder, as well as non-diagnosed bouts of anxiety. As a nootropic, Selank can help enhance mental sharpness, reduce mental fatigue, improve the ability to focus, improve cognitive functioning while in a sleep deficit, and enhance memory.
3.These effects are provided without the negative side effects typically associated , such as physical dependence, psychological addiction, and decreased motor ability. In fact, Selank is largely devoid of side effects, with the large majority of researchers claiming that it is a "side effect free" compound. This makes Selank more suitable for long-term use.
|MGF||2mg/vials, 10 vials/box|
|PEG MGF||2mg/vials, 10 vials/box|
|CJC-1295 with DAC||2mg/vials, 10 vials/box|
|CJC-1295 without DAC||2mg/vials, 10 vials/box|
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|Selank||5mg/vials, 10 vials/box|
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