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What is PT-141?
PT-141 is a libido peptide. It is used to treat sexual dysfunction in women as well as hemorrhagic shock, and reperfusion injury. It was available in a nasal spray until it was discontinued in 2008 after health concerns. It is now available as a substance to use for injection.
PT-141 came from the Melanotan testing that occurred in scientific studies. They noticed what while Melanotan and Melanotan II were successful in tanning skin without sunlight, the side effects were sexual arousal in men and women with erection benefits for men who had erectile dysfunction. In a third clinical trial, PT-141 was shown to enact the lordosis behavior in animal test subjects. It directly changes the chemicals in the brain that turn on during arousal without passing through the blood stream.
PT-141 Product Name: PT-141
PT-141 CAS: 32780-32-8
PT-141 MF: C50H69N15O10
PT-141 MW: 1040.17736
PT-141 Appearance: White powder
PT-141 Water Content(Karl Fischer): ≤ 5.0%
PT-141 Acetate Content(by HPLC): ≤ 15.0%
PT-141 Amino Acid Composition: ± 10% of theoretical
PT-141 Purity(by HPLC): ≥ 97.0%
PT-141 Single Impurity(by HPLC): ≤ 1.0%
PT-141 Peptide Content(by %N): ≥ 80%
PT-141 Assay(By Anhydrous, Acetic Acid-free): 95.0~105.0%
PT-141 Bacterial Endotoxins: ≤ 5EU/mg
PT-141 Grade: Pharmceutical Grade
PT-141 Storage: Shading, confined preservation.
PT-141(Bremelanotide)is the first of a new class of drugs called melanocortin agonists being developed to treat sexual dysfunction. The mechanism of action of PT-141 (Bremelanotide)may offer significant safety and efficacy benefits over currently available products because it acts on the pathway that controls sexual function without acting directly on the vascular system.
PT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).
PT-141 was developed from the tanning peptide Melanotan 2, which is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis that is known as alpha-Melanocyte stimulating hormone.
MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido. Resultantly,
PT-141 has been shown in studies to exhibit libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, but not skin tanning. Melanotan 1 and Melanotan 2 have been researched for their use in protecting against the harmful effects of ultraviolet radiation from sunlight due to their melanogenesis-stimulating properties.
PT-141, or bremelanotide, belongs to the new class of synthetic proteins that work as melanocortin agonists. It is a peptidic compound under new drug development process known as palatin technology. Its molecular formula is C50H68N14O10; Its molecular weight/mass is 1025.2.
The similarity of currently available (FDA-approved) mechanisms of medical treatment for ED means that medical practitioners are generally limited to treating patients with adverse reactions to this class (PDE5 inhibitors). As Hellstrom wrote:
The currently available agents of erectile dysfunction (ED) have the same mechanism of action and pharmacological properties. Therefore, they have the same limitations, including the focus on erection as a terminal organ process. One of the relatively undeveloped areas of research is the potential to have central agents to improve male sexual responses. Various neurohormonal and neurotransmitter systems are involved in male sexual responses, including testosterone, dopamine, serotonin and melanocortin systems. Studies are under way to determine the utility of centrally acting drugs as monotherapy or adjunctive therapy in men with ED or other forms of sexual dysfunction. Bremelanotide is a melanocortin agonist that has been tested in men with ED and can prove to be one of the first central acting agents with clinical utility in male sexual dysfunction.
PT-141 functions by activating the melanocortin 1 receptor and MC4R namely. Bremelanotide originally was tested for nasal spray delivery but was discontinued after concerns about side effects. Bremelanotide PT141, as Melanotan II, may cause spontaneous arousal enhancing effect. Unlike other supplements, pt 141 results do not act on the vascular body, but directly increases desires through the nervous system.
PT-141 or Bremelanotide is the generic term for a peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).
PT-141 has a similar structure to Melanotan-II and is a synthetic analogue of alpha-Melanocyte stimulating hormone (α-MSH). Alpha-MSH is an endogenous peptide that has potential influence over lipid metabolism, appetite, and sexual libido. PT-141 is a potential remedy for the treatment of sexual dysfunction and studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation.
|Product name||PT141 Acetate|
|CAS register number||32780-32-8|
|Amino Acid Composition||±10% of theoretical|
|Water Content(Karl Fischer)||≤6.0%|
Bremelanotide (PT-141) was developed from Melanotan 2 (MT-II).PT-141 is a metabolite of MT-II that lacks the C-terminal amide function-stripping away tanning properties.
PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation.
PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs.
PT-141,Used as an erectile dysfunction solution, it is used by men who want to bring back the fire into their sex life in terms of achieving rock-hard erections that do not only satisfy them but their partners as well. In the process, they never have to take any other medications or choose hormone replacement therapy again with it at their side.
1.PT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).
2.PT-141 is a potential remedy for the treatment of sexual dysfunction; Specifically, male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.
Developed From Melanotan II
Bremelanotide or PT-141, a research chemical and peptide, belongs to the classification known as melanocyte stimulating hormones (MSH). It is a hexapeptide analog of alpha-MSH, and was originally developed from the MSH Melanotan II, a peptide agent that was reviewed in trials for sunless tanning but, unexpectedly, resulted in sexual arousal and sexual spontaneous erections in nine of ten test subjects.
Bremelanotide is a compound under drug as a treatment for female and male sexual dysfunction, hemorrhagic shock and reperfusion injury.
Treatment of Sexual Dysfunction
Bremelanotide or PT-141 is the generic term for a new research peptide for use in helping improve sexual dysfunction in men (erectile dysfunction or impotence) as well as helping improve sexual dysfunction in women (sexual arousal disorder).
PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction.Bremelanotide, PT-141 does not act on the vascular system like the former compounds but it is known and has been shown to help increase sexual activity in both male and female mammals. Bremelanotide PT-141 allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation.
.5 mg = light
1.0mg = moderate
2.0mg = heavy
women are about half the dose of men.
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