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Hormones Polypeptide Peptide Melanotan II CAS 121062-08-6 Melanotan 2 For Skin Tanning and Male Sexual Dyfunction
Why chose MT-II :
For a bodybuilder planning to compete on stage, there is a considerable amount of time and attention to detail committed before they are ready to compete. Being muscled up and defined is only accentuated by a nice tan to make lines and definitions pop out and become more evident to viewers and judges. Enter the heptapeptide Melanotan II, now bodybuilders can actually protect themselves from over exposure to the sun while boosting melanin. This results in a darker and more tanned complexion. When Melanotan II is added to a peptide protocol leading up to a show, it will boost melanin levels, resulting in tanner skin; in addition, it will increase fat loss and muscle hardness.
CAS NO. :121062-08-6
Molecular Formula :C50H69N15O9
Molecular Weight :1024.18
Appearance :White Powder
Identity (ESI-MS) :1024.18±1.0
Source :Chemical Synthesis
Storage :Lyophilized Melanotan II is stable at room temperature for 90 days,however it should be stored in a freezer below -8C for any extended period of time. After reconstituting Melanotan II should be refrigerated at temperatures not to exceed 36 F.
Melanotan and melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone inducing skin tanning.
Like its predecessor, Melanotan I, MT 2 plays a role in stimulating melanogenesis and thus providing a protective mechanism against UV rays since under its actions melanocytes are able to increase production and secretion of hormone melanin.
Scientists were also able to notice another characteristic of this compound. MT 2 had a positive e!ect on libido due to its aphrodisiac properties. Scientists also found MT 2 had a mild positive fat-mobilizing e!ect.
|Appearance||White to off white powder||Consistent|
If you look hard enough out there, you will find some weird and wonderful dosaging schedules whereby the user calculates their daily dosage by multiplying their bodyweight by a cofactor. Perhaps this approach has been adopted since this has been the method employed in the ongoing clinical studies. Typically, this type of formula would suggest a dose of 1mg of MT-II per day for someone weighing in at a mere 110lb (50kg). The cynical among us might be forgiven for thinking that these formulae are constructed by those with a personal interest in the sale of the product as I believe this to be more than necessary to achieve a great result. Indeed, there are many instances whereby users feel they have become too dark. While I have no problem with a bodyweight dosage scale in principle, I can't help thinking that it's not only unnecessary (particularly for the mathematically challenged), but also avoids the ability to gradually increase dosages from a relatively low level; something which I would advocate to assess individual tolerance levels to side effects, especially in the case of MT-II.
Clinical trials to determine efficacy of the drugs have typically used dosages up to 0.21mg/kg daily for Melanotan (16mg for a 75kg (165lb) individual), and up to 0.03mg/kg daily for Melanotan II (2.25mg for a 75kg (165lb) individual). More typically however, trials have used the dosages of 0.16mg/kg (12mg) and 0.025mg/kg (1.875mg) respectively. At this level of dosage, one such study involving Melanotan indicated the following incidences of side effects from subjects:
Facial Flushing 75%
Injection site reactions 13%
Zero incidence of erections
No change in vital signs or haematological parameters, blood biochemistry (liver and renal function)
As is the case with any drug use, the user is ideally looking to minimise unwanted side effects, whilst still achieving an acceptable outcome. With this in mind, I would suggest that a tapering up of dosages is used in order to assess the individual's personal tolerance to the side effects.
Both MT and MT II can be used for extended periods, whereby there is an initial daily administration of perhaps 2-3 weeks or until desired level of pigmentation has been achieved, followed by a maintenance phase of two injections per week.
Effects of Melanotan II
The effects of Melanotan II two revolve around nothing more than tanning and possible erectile dysfunction relief. A darker and deeper tan may be noticed in a few days (assuming one is also tanning) and should produce notable results in a few weeks. The longer one uses Melanotan II the darker he will get.
The effects of Melanotan II on erectile dysfunction take approximately 4-6 hours to take effect and should last 6-12 hours depending on individual response. Timing is important if used for this purpose. However, there are those that run small daily to every other day doses in order to provide a maintenance relief, but this can prove problematic to the skin if not careful.
Melanotan 2 (also referred to as Melanotan II) is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis,a process responsible for pigmentation of the skin.
Melanotan II,a drug originally developed as a skin tanning agent,but subsequently investigated as a potential treatment for sexual dysfunction.
As a result,Melanotan 2 has been shown in studies to exhibit appetite suppressant,lipolytic,and libido-enhancing effects in addition to promoting skin tanning.
Melanotan 2 has been shown in studies to exhibit appetite suppressant,lipolytic,and libido-enhancing effects in addition to promoting skin tanning.
Melanotan 2 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
-- The Development of Melanotan II Acetate :
The initial creation of the synthetic Melanotan 2 peptide can be credited to the University of Arizona. During the course of research aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight. Initially, University of Arizona researchers attempted to directly administer the naturally occurring hormone alpha-MSH in order to elicit this desired result.
Although this strategy exhibited promising results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1 and Melanotan 2, which exhibit similar effects whilst possessing an extended half-life for functional therapeutic utilization.
Melanotan II is in the class of alphamelanocyte-stimulating hormone (alpha-MSH) mimetics. Alpha-MSH is produced in the pituitary, and activates alpha-melanocyte receptors. MT-II works in the same way.
There are a number of subtypes of alpha-melanocyte receptors (MC1-5.) Melanotan II is generally non-selective and activates multiple types. Activation of the MC1 receptor promotes skin pigmentation, while activation of the MC4 receptor can enhance tendency to penile erection.
For comparison, PT-141 is selective for the MC4 receptor and therefore promotes penile erection while having little or no effect on skin pigmentation.
Melanotan II can have appetite suppressive effects, but rarely to a degree providing either a problem for bulking or much of an aid for dieting. Where hair is light colored MT-II use can darken it, though the effect on hair is much less than on the skin and generally is unnoticed. It's also possible for feelings of nausea, light-headedness, or tiredness to occur. Any of these undesired effects, if occurring, will clear quickly. Increased growth, increased number, or hyperpigmentation of moles may occur. These side effects, if they occur, may last for a substantial period of time or even be permanent. Accordingly, effect on moles should be monitored.
Melanotan II is an effective injectable peptide product to enhance ability to tan. Dosing is typically 0.5 to 1.0 mg/day, and the total amount needed for good effect is typically 30-40 mg, though for individuals of medium darkness already, it may be as low as 10 mg for significant effect. MT-II can also be used to enhance tendency to penile erection, but frequency of such use needs to be limited to avoid excessive total effect on skin pigmentation.
Freezing vials is permitted for unmixed vials only (i.e. vials still in powder form and not
reconstituted with water), however, they should only ever be frozen and thawed out again
once as repeated freeze/thaw cycles can damage the peptide chain. Since vials remain stable
in the refrigerator for 12 months (1 year), freezing vials should be reserved for situations
where you plan on storing unmixed vials for more than 12 months.
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