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CAS 317318-84-6 98% Purity White SARMs Raw Powder GW-0742/GW 610742

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Good quality Testosterone Anabolic Steroid for sales
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CAS 317318-84-6 98% Purity White SARMs Raw Powder GW-0742/GW 610742

China CAS 317318-84-6 98% Purity White SARMs Raw Powder GW-0742/GW 610742 supplier
CAS 317318-84-6 98% Purity White SARMs Raw Powder GW-0742/GW 610742 supplier CAS 317318-84-6 98% Purity White SARMs Raw Powder GW-0742/GW 610742 supplier CAS 317318-84-6 98% Purity White SARMs Raw Powder GW-0742/GW 610742 supplier

Large Image :  CAS 317318-84-6 98% Purity White SARMs Raw Powder GW-0742/GW 610742

Product Details:

Place of Origin: China
Brand Name: LSW
Certification: GMP,SGS,BV,ISO
Model Number: 317318-84-6

Payment & Shipping Terms:

Minimum Order Quantity: 10gram
Price: Negotiable
Packaging Details: Disguised package &Foil bag or according to customs need
Delivery Time: Within 24 hours after payment
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 1000kg/Month
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Detailed Product Description
CAS: 317318-84-6 Character: White Powder
Purity: 98% Usage: Bodybuilding&athletes Competition
MF: C21H17F4NO3S2 MW: 471.49

CAS 317318-84-6 98% Purity White SARMs Raw Powder GW-0742/GW 610742
 
Description:
 
GW0742 is a high affinity PPAR agonist reduces lung inflammation induced by bleomycin instillation in mice.A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator.
 
These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. Theperoxi some proliferator-activated receptor (PPAR) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 M.
 
The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR).
 
Surprisingly, GW0742 behaved as PPARagonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.
 
The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1, IGFBP-3 and TRPV6 were negatively regulated by GW0742. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.
 
Quick details:
 
Product name: GW 0742
 
Other name: GW 610742
 
Chemical name: 2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid
 
CAS NO. 317318-84-6
 
MF : C21H17F4NO3S2
 
MW: 471.49
 
Purity: 98%
 
Appearance: White powder
 
Packing: Well Disguised Package or as your Requirement
 
Storage temp 2-8 C
 
Usage : It had been investigated as a potential treatment for obesity,diabetes,dyslipidemia and cardiovascular disease .
 
Applications:
 
GW0742 is a synthetic high affinity PPAR β/δ agonist, and its possible role in preventing the advance of inflammatory and apoptotic processes induced by bleomycin, that long-term leads to the appearance of pulmonary fibrosis. Our data showed that GW0742-treatment (0.3 mg/Kg, 10 percent DMSO, i.p.) has therapeutic effects on pulmonary damage, decreasing many inflammatory and apoptotic parameters detected by measurement of: 1) cytokine production; 2) leukocyte accumulation, indirectly measured as decrease of myeloperoxidase (MPO) activity; 3) IkBα degradation and NF-kB nuclear translocation; 4) ERK phosphorylation; 5) stress oxidative by NO formation due to iNOS expression; 6) nitrotyrosine and PAR localization; 7) the degree of apoptosis, evaluated by Bax and Bcl-2 balance, FAS ligand expression and TUNEL staining. Taken together, our results clearly show that GW0742 reduces the lung injury and inflammation due to the intratracheal BLEO--instillation in mice.
 
Advantage:
 
1. We have professional team for package and shipment. Fast and discreet shipment could be arranged for customs pass Guaranteed.we are a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
 
 
2. Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
 
 
3. Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand.
 
 
4. Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
 
 
5. High quality, good price, fast and safety delivery. Shipment by DHL, TNT, FEDEX, HKEMS, UPS, etc.
 
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CAS 317318-84-6 98% Purity White SARMs Raw Powder GW-0742/GW 610742
 
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