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|CAS:||50-41-9||Character:||White Crystalline Powder|
|Purity:||99.5%||Usage:||Anti Estrogen Steroids|
Clomifene citrate / Clomid CAS: 50-41-9 Anti Estrogen Steroids GMP Factory
Clomifene citrate (Clomid)
Another name:2-4-[2-Chloro-1,2-diphenylethenyl]phenoxy-N,N-diethylethanamine citrate
Alias:serophene; pergotime; clomphid; Clomid
CAS NO: 50-41-9
Structural formula: C26H28ClNO C6H8O7
Molecular weight: 598.11
Appearance: white or milky white crystalline powder
Use: the goods to anti-estrogen fertility inducer, the objects in dysfunctional uterine bleeding, polycystic ovary, menstrual disorders and drug-induced amenorrhea and other gynecologic diseases.
Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate.This includes those who have polycystic ovary syndrome. Use results in a greater chance of twins. It is taken by mouth once a day.
Common side effects include pelvic pain and hot flushes. Other side effects can include changes in vision, vomiting, trouble sleeping, ovarian cancer, and seizures. It is not recommended in people with liver disease or who are pregnant. Clomifene is in the selective estrogen receptor modulator (SERM) family of medication. It works by causing the release of GnRH by the hypothalamus, and subsequently gonadotropin from the anterior pituitary.
Clomifene was approved for medical use in the United States in 1967. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available as a generic medication. The wholesale cost in the developing world is about 0.79 to 2.00 USD for a course of treatment. In the United States the wholesale cost of a course of treatment is 4.80 USD. Its introduction began the era of assisted reproductive technology.
How does Clomid work?
Clomid blocks the hormone estrogen from interacting with your pituitary gland. When estrogen interacts with the pituitary gland, less luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are produced. This leads to a decrease in testosterone and therefore decreased production of sperm. Because Clomid blocks estrogen’s interaction with the pituitary gland, there is an increase in LH, FSH, and testosterone in the body.
Optimal dosing in men hasn’t been established. The dose given can range from 12.5 to 400 milligrams (mg) per day. A recent review recommends starting dosage at 25 mg three days per week and then increasing to a dose of 50 mg per day as needed. High doses of Clomid can actually have a negative effect on sperm count and motility.
DOSAGE AND ADMINISTRATION:
The workup and treatment of candidates for CLOMID therapy should be supervised by physicians experienced in management of gynecologic or endocrine disorders. Patients should be chosen for therapy with CLOMID only after careful diagnostic evaluation (see INDICATIONS). The plan of therapy should be outlined in advance. Impediments to achieving the goal of therapy must be excluded or adequately treated before beginning CLOMID. The therapeutic objective should be balanced with potential risks and discussed with the patient and others involved in the achievement of a pregnancy.
Ovulation most often occurs from 5 to 10 days after a course of CLOMID. Coitus should be timed to coincide with the expected time of ovulation. Appropriate tests to determine ovulation may be useful during this time.
Treatment of the selected patient should begin with a low dose, 50 mg daily (1 tablet) for 5 days. The dose should be increased only in those patients who do not ovulate in response to cyclic 50 mg CLOMID. A low dosage or duration of treatment course is particularly recommended if unusual sensitivity to pituitary gonadotropin is suspected, such as in patients with polycystic ovary syndrome (see WARNINGS; Ovarian Hyperstimulation Syndrome).
The patient should be evaluated carefully to exclude pregnancy, ovarian enlargement, or ovarian cyst formation between each treatment cycle.
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