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|CAS Number:||62-44-2||Names:||Phenacetin, 4-acetophenetidine|
|Molecular Formula:||C10H13NO2||Molecular Weight:||179.22|
|Storage:||Cool, Dry Place||Usage:||Fever Reducer Drug|
Fever Reducer Phenacetin CAS: 62-44-2 Pharmaceutical Grade White Powder
Chemical name: Phenacetin
CAS No.: 62-44-2
Molecular formula: C10H13NO2
Molecular weight: 179.22
Melting point: 133-136 °C(lit.)
Boiling point: 132 °C / 4mmHg
Density: 1.046 g/mL at 25 °C
Stability: Stable. Incompatible with strong oxidizing agents, strong acids.
Appearance: White and shiny crystalline powder that is soluble in hot water, chloroform, and other polar solvents.
Usage: Antipyretic analgesics; Treatment of fever; Scientific experiment; Pain-relieving and fever-reducing drug.
|Test Items||Specification||Test Results|
|Description||Should comply with the standard||Pass|
|Identification||Should be positive reaction||Pass|
|P-Phenetidine||Brownish red 4#||Pass|
|4-chloroacetanilide||Should comply with standard||Pass|
|Melting point||134ºC to 137ºC||134ºC to 137ºC|
|Conclusion||Complies with BP68 edition|
Description and Application:
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India. As a result, some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity. Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs. Due to low cost phenacetin is used for research into the physical and refractive properties of crystals.It is an ideal compound for this type of research.
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