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|Synonyms:||1-Oxacyclopentan-2-one;2(3H)-dihydrofuranone;Gamma Butyrolactone, 1, 4- Butyrolactone,;γ -Butyroladone,;GBL; BLO,||CAS No:||96-48-0|
|Melting Point:||-45℃||Appearance:||Colorless Transparent Liquid|
Colourless liquid gamma-Butyrolactone (GBL) Sex Enhance Pharmaceutical Raw Material CAS 96-48-0
GBL is an important chemical raw material and intermediate for medicine, and also the intermediate of the synthesize N-methyl pyrrolidone, α -pyrrolidone, polyvinyl pyrrolidone, α -acetyl-γ -butyrolactone, methionine and the butyric acid compounds.
This product features a strong solubility, and is a good solvent for polyacrylonitrile, epoxy resin, polyvinyl butyral, polyvinyl chloride and its copolymers, and cellulose polymers. In medical industry, it is mainly used in synthesizing cyclopropylamine, etc.
Gamma butyrolactone (GBL) is a chemical compound that can be synthesized in laboratories but can also be found in unadulterated wines. On its own, gamma butyrolactone does not have any effects.Nevertheless, when it is absorbed into the blood, it is subjected to the action of lactonase enzymes. These enzymes catalyze the conversion of gamma butyrolactone into gamma hydroxybutyric acid (GHB).
As a prodrug of GHB, gamma butyrolactone is sometimes referred to as dehydrated GHB. As indicated by the term " dehydrated," GBL does not contain as much water as GHB, and is therefore more fat-loving, or lipophilic. Compared with GHB, GBL is absorbed faster when consumed with food. This causes it to produce the desired effects faster. The duration of action of gamma butyrolactone, however, is also shorter than that of its counterpart.
The effects of gamma butyrolactone are based on its property as a prodrug of GHB. GHB is similar to the naturally produced neurotransmitter called gamma aminobutyrate (GABA). GABA is produced by the brain and acts on receptors to block nerve impulses, thereby earning the label " inhibitory" neurotransmitter. The effects of GABA include relaxation, sleep, an increased feeling of well-being, decreased anxiety and decreased muscle tone. Furthermore, GABA release is associated with increased levels of growth hormone.
Product name :Gamma-Butyrolactone,GBL
Synonyms:1-Oxacyclopentan-2-one;2(3H)-dihydrofuranone;Gamma Butyrolactone, 1, 4- Butyrolactone,;γ -Butyroladone,;GBL; BLO,
Melting point: -45℃
Appearance:Colorless transparent liquid
Usage: Used as pharmaceutical intermediate, industry solvent, diluents, curing agent.
|Appearance||Colorless clear liquid||Colorless clear liquid|
|Purity (wt%, GC)||≥99.80||99.80|
|Moisture (wt%, K.F.)||≤0.03||0.020|
|Glycol (wt%, GC)||≤0.02||0.003|
|Tetrahydrofuran (wt%, GC)||≤0.03||0.024|
|Conclusion: It conforms to electron level|
How to use:
R-butyrolactone is an important organic chemical raw material, which is widely used in the pharmaceutical, pesticide, petrochemical and other industries.
1 ) It can be used to synthesize pyrrolidone products;
2 ) It can be used as a pharmaceutical intermediate, such as Cyclopropylamine and vitamin;
3 ) It can be used as a pesticide intermediate, such as herbicide and plant growth regulator;
4 ) It can be used for alkenes, alkynes extraction agent, absorbent and dispersing agent;
5 ) It can be used to synthesize resin as an antioxidant, plasticizer, dispersing agent, fixing agent and solvent;
6 ) It can be used to synthesize fiber spinning solvent, coagulant, dyeing assistant and antistatic agent;
7 ) It can be used as a raw material of color film former, electrolyte, capacitor and ink lubricant.
GBL has been found in extracts from samples of unadulterated wines.This finding indicates that GBL is a naturally occurring component in some wines and may be present in similar products.
The concentration detected was approximately 5 μg/mL and was easily observed using a simple extraction technique followed by GC/MS analysis. GBL can be found in cheese flavourings but typically results in a content of 0.0002% GBL in the final foodstuff.
Gamma-Butyrolactone is a hygroscopic colorless liquid with a weak characteristic odor which is soluble in water. is a common solvent and reagent in chemistry as well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for, and it is used as a recreational intoxicant with effects similar to alcohol.
Gamma-Butyrolactone has been found in extracts from samples of unadulterated wines. This finding indicates that Gamma-Butyrolactone is a naturally occurring component in some wines and may be present in similar products. The concentration detected was approximately 5 μg/mL and was easily observed using a simple extraction technique followed by GC/MS analysis. Gamma-Butyrolactone can be found in cheese flavourings but typically results in a content of 0.0002%Gamma-Butyrolactone in the final foodstuff.
Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, Gamma-Butyrolactone can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.
Gamma-Butyrolactone is not active in its own right; its mechanism of action stems from its identity as a prodrug of .
The hypnotic effect of is enhanced by combination with alcohol. A 2003 rat study showed that Gamma-Butyrolactone in combination with ethanol showed a potentiated hypnotic effect, as the sleep-timing measure was longer than both of the individual components combined
Gamma-Butyrolactone is rapidly converted into by paraoxonase (lactonase) enzymes, found in the blood. Animals which lack these enzymes exhibit no effect from Gamma-Butyrolactone. Gamma-Butyrolactone is more lipophilic (fat soluble) than, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, Gamma-Butyrolactone tends to be more potent and faster-acting than, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than.
1) GBL Magic Cleaner has a unique cleaning strength.
2) GBL is used to produce the related GHB. GHB has been classified as a Class C drug.
3) people take gamma butyrolactone (GBL) for improving sleep, athletic performance and sexual performance and pleasure.
They also take it for relieving depression and stress, promoting clear thinking, prolonging life, causing relaxation, and releasing hormone. GBL is also used to trim fat and as a body- or muscle-builder. Some people take it as a recreational drug.
The appropriate dose of gamma butyrolactone (GBL) depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for gamma butyrolactone (GBL).
Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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