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|Melting Point:||130.14 °C||MF:||C17H19N5|
Anastrozole CAS: 120511-73-1 Arimidex Powder Anti-Estrogen Steroids Bodybuilding Supplement 99%
Anastrozole, sold under the trade name Arimidex among others, is a medication used in addition to other treatments for breast cancer. Specifically it is used for hormone receptor-positive breast cancer. It has also been used to prevent breast cancer in those at high risk. It is taken by mouth.
Common side effects include hot flashes, altered mood, joint pain, and nausea. Severe side effects include an increased risk of heart disease and osteoporosis. Use during pregnancy is known to harm the baby. Anastrozole is in the aromatase-inhibiting family of medications. It works by blocking the creation of estrogen.
Chemical Names: Anastrozole; 120511-73-1; Arimidex; Anastrazole; Anastrozol; Anastrole More...
Molecular Formula: C17H19N5
Molecular Weight: 293.374
Melting Point: 130.14 °C
Solubility: Freely soluble in methanol, acetone, ethanol, tetrahydrofuran; very soluble in acetonitrile.
Vapor Pressure: 1.19X10-8 mm Hg at 25 deg C (est)
Appearance: White powder.
|Description||White crystalline powder||Complies|
|Identification||IR HPLC Reactive||Conform with standard IR Conform with standard HPLC Conform|
|Solubility||Freely soluble in methanol,acetone,ethanol and tetrahydrofuran.And very soluble in acetonitrile||Complies|
|Total Unspecified Impurity||max. 0.2%||0.08%|
|Individual unspecified impurlty||max. 0.1%||0.05%|
|Related compound B||max. 0.2%||0.07%|
|Related compound C||max. 0.2%||0.04%|
|Related compound D||max. 0.1%||0.05%|
|Related compound E||max. 0.1%||0.06%|
|Limit of cyclohexane||max. 0.08%||ND|
|Limit of ethylacetate||max. 0.1%||0.07%|
|Residue on ignition||max. 0.1%||0.07%|
|Storage||Cool and dry|
|Conclusion||It complies to USP32 .|
Anastrozole (an as' troe zole) is a nonsteroidal inhibitor of aromatase, the enzyme responsible for the conversion of testosterone to estrone (E1) and of androstenedione to estradiol (E2). Highest levels of aromatase are found in the ovary and placenta, which are the major sources of estrogen in premenopausal women. However, aromatase is also found in other tissues, such as liver, kidney, adrenals, brain, muscle and subcutaneous fat where it is also active in producing estrogens, although at low levels. These tissues are the major source of estrogen in postmenopausal women. Inhibitors of aromatase were developed to block the synthesis of estrogen in the peripheral tissues and, thus, as antiestrogen therapy of estrogen receptor positive breast cancer in postmenopausal women. The aromatase inhibitors in current use include letrozole, exemestane and anastrozole.
Anastrozole is a nonsteroidal, specific aromatase inhibitor which has little or no effect on adrenal glucocorticoid or mineralocorticoid synthesis. Anastrozole was approved for use in postmenopausal women with breast cancer in the United States in 1995. Anastrozole is available in 1 mg tablets in generic forms and under the brand name Arimidex. Its current indications are as adjuvant therapy in postmenopausal women with hormone responsive breast cancer, as first line therapy of locally invasive or metastatic estrogen receptor positive breast cancer in postmenopausal women, and as adjuvant therapy in postmenopausal women with advanced breast cancer not responsive to tamoxifen. It is typically given in single oral doses of 1 mg daily for up to five years. Common side effects include hot flashes, night sweats, fatigue, dizziness, headache, abdominal discomfort, nausea, arthralgias, weight gain and rash.
How anastrozole works:
Hormones are substances produced naturally in the body. They act as chemical messengers and help control the activity of cells and organs. Hormonal therapies interfere with the way hormones are made or how they work in the body.
Many breast cancers rely on the hormone oestrogen to grow. This type of breast cancer is called oestrogen receptor-positive (ER positive) breast cancer.
After the menopause, oestrogen is no longer made in the ovaries. Instead, it’s made in the fatty tissues of the body. This happens when an enzyme called aromatase changes other hormones into oestrogen. Anastrozole is a drug called an aromatase inhibitor. It blocks this process and reduces the amount of oestrogen in the body.
How to take anastrozole:
Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about anastrozole and will provide you with a full list of the side-effects which you may experience from taking it.
Take one 1 mg tablet of anastrozole each day, exactly as your doctor tells you to. Your dose will be printed on the label of the tablet pack to remind you.
You may take anastrozole at whatever time of day you find easiest to remember, but try to take your doses at the same time each day. This will help you to avoid missing any doses.
You can take the tablet before or after a meal.
If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.
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